Functional relevance | Gene name | SNP rs ID | Genetic model | Obesity status | OR [95%CI] | P value | Woolf test | Risk allele frequency | |
---|---|---|---|---|---|---|---|---|---|
T2D | NG | ||||||||
Insulin action | ADIPOQ | rs17300539 | Dominant | Non-obese | 0.96 [0.77–1.20] | 0.71 | 0.5 | 0.09 | 0.10 |
Obese | 1.07 [0.84–1.35] | 0.58 | 0.10 | 0.09 | |||||
All together | 0.99 [0.86–1.15] | 0.91 | 0.10 | 0.09 | |||||
ADIPOQ | rs266729 | Dominant | Non-obese | 1.00 [0.85–1.19] | 0.97 | 0.07 | 0.26 | 0.26 | |
Obese | 1.25 [1.04–1.49] | 0.015 | 0.25 | 0.24 | |||||
All together | 1.08 [0.96–1.21] | 0.18 | 0.25 | 0.25 | |||||
ENPP1 | rs1044498 | Additive | Non-obese | 0.99 [0.84–1.17] | 0.94 | 0.02 | 0.15 | 0.15 | |
Obese | 1.30 [1.10–1.54] | 0.003 | 0.17 | 0.14 | |||||
All together | 1.15 [1.03–1.28] | 0.014 | 0.16 | 0.15 | |||||
PPARG | rs1801282 | Recessive | Non-obese | 0.85 [0.69–1.05] | 0.136 | 0.24 | 0.91 | 0.89 | |
Obese | 0.73 [0.58–0.90] | 0.004 | 0.90 | 0.87 | |||||
All together | 0.81 [0.71–0.94] | 0.004 | 0.90 | 0.89 | |||||
RETN | rs1862513 | Recessive | Non-obese | 0.81 [0.60–1.09] | 0.16 | 0.11 | 0.30 | 0.30 | |
Obese | 1.14 [0.84–1.55] | 0.42 | 0.30 | 0.31 | |||||
All together | 1.00 [0.82–1.22] | 0.99 | 0.30 | 0.30 | |||||
Beta-cell defect | GCK | rs1799884 | Additive | Non-obese | 1.23 [1.06–1.45] | 0.009 | 0.55 | 0.20 | 0.17 |
Obese | 1.15 [0.97–1.35] | 0.12 | 0.19 | 0.18 | |||||
All together | 1.20 [1.08–1.34] | 0.001 | 0.19 | 0.18 | |||||
HNF1A | rs1169288 | Additive | Non-obese | 1.14 [1.01–1.30] | 0.042 | 0.06 | 0.34 | 0.32 | |
Obese | 0.96 [0.84–1.10] | 0.53 | 0.32 | 0.34 | |||||
All together | 1.02 [0.93–1.11] | 0.71 | 0.33 | 0.32 | |||||
HNF4A | rs1884614 | Additive | Non-obese | 1.06 [0.90–1.24] | 0.51 | 0.94 | 0.17 | 0.17 | |
Obese | 1.05 [0.89–1.25] | 0.54 | 0.17 | 0.17 | |||||
All together | 1.03 [0.93–1.15] | 0.58 | 0.17 | 0.17 | |||||
HNF4A | rs2144908 | Additive | Non-obese | 1.08 [0.92–1.27] | 0.33 | 0.75 | 0.18 | 0.17 | |
Obese | 1.04 [0.88–1.24] | 0.63 | 0.17 | 0.17 | |||||
All together | 1.04 [0.94–1.16] | 0.45 | 0.17 | 0.17 | |||||
KCNJ11 | rs5219 | Dominant | Non-obese | 0.93 [0.78–1.10] | 0.38 | 0.8 | 0.37 | 0.38 | |
Obese | 0.96 [0.80–1.15] | 0.68 | 0.37 | 0.37 | |||||
All together | 0.90 [0.80–1.01] | 0.085 | 0.37 | 0.38 | |||||
SLC30A8 | rs13266634 | Additive | Non-obese | 0.87 [0.76–0.99] | 0.043 | 0.37 | 0.73 | 0.70 | |
Obese | 0.95 [0.82–1.09] | 0.44 | 0.73 | 0.71 | |||||
All together | 0.91 [0.83–0.99] | 0.033 | 0.73 | 0.70 | |||||
TCF7L2 | rs7903146 | Additive | Non-obese | 1.89 [1.67–2.14] | 4.5 × 10 -23 | 3.2 × 10 -5 | 0.45 | 0.30 | |
Obese | 1.30 [1.14–1.48] | 1.1 × 10 -4 | 0.36 | 0.30 | |||||
All together | 1.59 [1.46–1.73] | 7.9 × 10 -27 | 0.40 | 0.30 |