Gene | Gene or Chromosomal area was implicated in: | Variation | Polymorphism was implicated in: |
---|---|---|---|
LPA 6q27 | • The metabolic syndrome [15] which is characterised by insulin resistance | G121A |  |
CBS 21q22.3 | • Hyperhomocysteinemia [16] which, in turn, is related to diabetic nephropathy [17]. | Ile278Thr | • Homocysteinuria [18]. |
APOB 2p24 |  | Thr71Ile | • Interaction between ApoB (Thr71Ile) and glucose tolerance on lipid parameters [19] |
SCNN1A 12p13 | • Same chromosomal region as GNB3 | Thr663Ala | • SCNN1A(Thr663Ala) was associated with fasting insulin levels, even after correction for BMI [20]. |
APOC3 11q23 | • Well-known diabetes region [21]. | C-641A |  |
 | • APOC3(C-482T) was associated with fasting insulin [22] and in interaction with LIPC -514 C>T also on glucose tolerance [23]. |  |  |
APOA4 11q23 | • Contained in the same region as Apo C-III | Gln360His | • Plasma glucose in women [24]. |
APOC3 11q23 | • Well-known diabetes region [21]. | C1100T |  |
 | • APOC3(C-482T) was associated with fasting insulin [22] and in interaction with LIPC -514 C>T also on glucose tolerance [23] |  |  |
F7 13q34 | • Chromosomal area implicated in the insulin-response-to-glucose in DM2 [25]. | -323 10-bp Ins/Del |  |