Table 1 Applicability and ease of use of risk assessment models.
From: Selecting a BRCA risk assessment model for use in a familial cancer clinic
| Â | Calculation method | Cancers included | Inclusiveness | Family history required | Data entry |
|---|---|---|---|---|---|
BRCAPRO | CaGene 4.3 software | Male and female breast and ovarian cancer | All individuals | 1st and 2nd degree relatives | Complete pedigree data entered for affected and unaffected |
Myriad II | CaGene 4.3 software | Male and female breast and ovarian cancer | All individuals | 1st and 2nd degree relatives | Data searchable by established tables or data entry on CaGene 4.3 software |
Couch | CaGene 4.3 software | Male and female breast and ovarian cancer | Excludes probands from families with only ovarian or male breast cancer | 1st and 2nd degree relatives | Data searchable by established table or data entry on CaGene 4.3 software |
Ontario Family History Assessment Tool (FHAT) | CaGene 4.3 software | Male and female breast, ovarian, colon (<50 yrs), prostate cancer (<50 yrs) | All individuals | 1st and 2nd degree relatives | Data searchable by established table or data entry on CaGene 4.3 software |
Manchester | Hand calculations | Male and female breast, ovarian, prostate and pancreatic cancer | Excludes Ashkenazi Jewish | 1st, 2nd, and 3rd degree relatives | Scoring system |
Penn II | Web-based | Male and female breast, ovarian, prostate and pancreatic cancer | Excludes probands from families with no breast cancer cases | 1st, 2nd, and 3rd degree relatives | One page questionnaire |
IBIS | Down-loadable software | Female breast and ovarian cancer | Includes only females unaffected by breast cancer | 1st, 2nd, and 3rd degree relatives | One page questionnaire |
BOADICEA | Web-based | Breast, ovarian, prostate and pancreatic cancer | All individuals | 1st, 2nd, and 3rd degree relatives | Complete pedigree data entered for affected and unaffected |