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Table 1 Phenotype distribution, examination cycle, and numbers of participants with subclinical atherosclerosis phenotypes

From: Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study

Subclinical atherosclerosis measure

Phenotype Variable name

N

Offspring, exam

Covariate adjustment

Ankle-brachial index

RANKLEBI6

984

Offspring, 6

Age, sex-specific

 

RANKLEBI6MV

984

Offspring, 6

Age, smoking, diabetes, hypertension, total cholesterol/HDL ratio, log triglyceride, sex-specific

 

RANKLEBI7

982

Offspring, 7

Age, sex-specific

 

RANKLEBI7MV

982

Offspring, 7

Age, smoking, diabetes, hypertension, total cholesterol/HDL ratio, log triglyceride, sex-specific

Maximum carotid artery bulb IMT

RNKCAROTBULBAS6

959

Offspring, 6

Age, sex-specific

 

RNKCAROTBULBMV6

951

Offspring, 6

Age, treatment-adjusted systolic blood pressure, BMI, cigarettes per day, HDL cholesterol, total cholesterol, diabetes, log triglyceride, and in women, menopausal status, hormone therapy, sex-specific

Maximum common carotid artery IMT

RNKCAROTCCAMAXAS6

978

Offspring, 6

Age, sex-specific

 

RNKCAROTCCAMAXMV6

969

Offspring, 6

Age, treatment-adjusted systolic blood pressure, BMI, cigarettes per day, HDL cholesterol, total cholesterol, diabetes, log triglyceride, and in women, menopausal status, hormone therapy, sex-specific

Mean common carotid artery IMT

RNKCAROTCCAMEANAS6

978

Offspring, 6

Age, sex-specific

 

RNKCAROTCCAMEANMV6

969

Offspring, 6

Age, treatment-adjusted systolic blood pressure, BMI, cigarettes per day, HDL cholesterol, total cholesterol, diabetes, log triglyceride, and in women, menopausal status, hormone therapy, sex-specific

Maximum internal carotid artery IMT

RNKCAROTICAMAXAS6

888

Offspring, 6

Age, sex-specific

 

RNKCAROTICAMAXMV6

880

Offspring, 6

Age, treatment-adjusted systolic blood pressure, BMI, cigarettes per day, HDL cholesterol, total cholesterol, diabetes, log triglyceride, and in women, menopausal status, hormone therapy, sex-specific

Mean internal carotid artery IMT

RNKCAROTICAMEANAS6

888

Offspring, 6

Age, sex-specific

 

RNKCAROTICAMEANMV6

880

Offspring, 6

Age, treatment-adjusted systolic blood pressure, BMI, cigarettes per day, HDL cholesterol, total cholesterol, diabetes, log triglyceride, and in women, menopausal status, hormone therapy, sex-specific

Maximum carotid artery stenosis

RNKCAROTSTENAS6

977

Offspring, 6

Age, sex-specific

 

RNKCAROTSTENMV6

968

Offspring, 6

Age, treatment-adjusted systolic blood pressure, BMI, cigarettes per day, HDL cholesterol, total cholesterol, diabetes, log triglycerides, menopausal status, hormone therapy, sex-specific

Mean abdominal aortic calcification

RESMDCTAACAS7

675

Offspring, 7

Age, sex-specific

 

RESMDCTAACMV7

673

Offspring, 7

Age, BMI, current cigarette smoking status, diabetes, systolic blood pressure, anti-HTN therapy, total-to-HDL-C ratio, lipid therapy, sex-specific

Mean coronary artery calcification

RESMDCTCACAS7

680

Offspring, 7

Age, sex-specific

 

RESMDCTCACMV7

678

Offspring, 7

Age, BMI, current cigarette smoking status, Diabetes, systolic blood pressure, anti-HTN therapy, total-to-HDL cholesterol ratio, lipid therapy, sex-specific

Maximum coronary artery calcification

RESMDCTCACMAXAS7

680

Offspring, 7

Age, sex-specific

 

RESMDCTCACMAXMV7

678

Offspring, 7

Age, BMI, current cigarette smoking status, diabetes, systolic blood pressure, anti-HTN therapy, total-to-HDL cholesterol ratio, lipid therapy, sex-specific

  1. Abbreviations: IMT = intimal medial thickness; MDCT = multidetector Computed Tomography; AAC = abdominal aortic calcification; CAC = coronary artery calcification; HDL = high density lipoprotein; BMI = body mass index; anti-HTN therapy = drug treatment for hypertension; lipid therapy = drug treatment for hyperlipidemia.
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BMC Medical Genetics

ISSN: 1471-2350

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