4A. Associations of averaged echo traits | |||||
---|---|---|---|---|---|
Candidate Gene | FHS 100K SNP | Physical Position | Trait | GEE p-value | FBAT p-value |
ACE | no SNP was associated with a p value < 0.05 for any LV trait studies | ||||
ADRB1 | rs10510001 | 115962372 | LV diastolic dimension | 0.004 | 0.0002 |
 | rs10510001 | 115962372 | LV systolic dimension | 0.001 | 0.001 |
 | rs10510000 | 115961985 | LV diastolic dimension | 0.052 | 0.001 |
 | rs10510000 | 115961985 | LV systolic dimension | 0.059 | 0.001 |
 | rs7902873 | 115884949 | LV diastolic dimension | 0.467 | 0.002 |
 | rs10509999 | 115917269 | LV diastolic dimension | 0.136 | 0.003 |
 | rs180940 | 115712401 | LV wall thickness | 0.003 | 0.072 |
 | rs180934 | 115720720 | LV wall thickness | 0.005 | 0.090 |
 | rs180935 | 115720249 | LV wall thickness | 0.005 | 0.160 |
 | rs998334 | 115957002 | LV diastolic dimension | 0.289 | 0.005 |
 | rs7902873 | 115884949 | LV systolic dimension | 0.249 | 0.006 |
 | rs10509999 | 115917269 | LV systolic dimension | 0.036 | 0.008 |
 | rs180935 | 115720249 | LV mass | 0.011 | 0.409 |
 | rs180934 | 115720720 | LV mass | 0.015 | 0.411 |
 | rs7902873 | 115884949 | LV mass | 0.646 | 0.016 |
 | rs998334 | 115957002 | LV systolic dimension | 0.110 | 0.018 |
 | rs10510001 | 115962372 | LV fractional shortening | 0.021 | 0.056 |
 | rs10510000 | 115961985 | LV fractional shortening | 0.382 | 0.027 |
 | rs180940 | 115712401 | LV mass | 0.029 | 0.303 |
 | rs10510001 | 115962372 | LV mass | 0.393 | 0.040 |
 | rs6585258 | 115739125 | LV mass | 0.047 | 0.481 |
 | rs10510000 | 115961985 | LV mass | 0.335 | 0.048 |
AGT | rs10495300 | 227188497 | Left atrial diameter | 0.095 | 0.001 |
 | rs2478518 | 227174605 | LV fractional shortening | 0.028 | 0.238 |
 | rs1202585 | 227309949 | LV wall thickness | 0.030 | 0.028 |
 | rs2180478 | 227295655 | LV diastolic dimension | 0.800 | 0.030 |
 | rs758216 | 227005969 | Aortic root diameter | 0.031 | 0.341 |
 | rs1202524 | 227257907 | LV diastolic dimension | 0.323 | 0.037 |
 | rs2478518 | 227174605 | LV systolic dimension | 0.038 | 0.467 |
 | rs731824 | 227329806 | Left atrial diameter | 0.043 | 0.399 |
 | rs1202585 | 227309949 | LV mass | 0.044 | 0.117 |
AGTR1 | rs1059502 | 150045008 | Aortic root diameter | 0.598 | 0.005 |
 | rs1357424 | 149801524 | LV fractional shortening | 0.075 | 0.006 |
 | rs1357424 | 149801524 | LV systolic dimension | 0.241 | 0.030 |
 | rs1059502 | 150045008 | LV diastolic dimension | 0.142 | 0.030 |
 | rs2331406 | 150048180 | Aortic root diameter | 0.589 | 0.032 |
 | rs10513333 | 149786557 | Left atrial diameter | 0.437 | 0.039 |
VEGF | rs729761 | 43912549 | LV fractional shortening | 0.012 | 0.200 |
 | rs729761 | 43912549 | Left atrial diameter | 0.573 | 0.018 |
 | rs729761 | 43912549 | LV systolic dimension | 0.018 | 0.249 |
 | rs2396083 | 43912786 | LV fractional shortening | 0.026 | 0.250 |
 | rs2396083 | 43912786 | Left atrial diameter | 0.489 | 0.031 |
 | rs2396083 | 43912786 | LV systolic dimension | 0.040 | 0.224 |
NOS3 | No SNP was associated with a p value < 0.05 for any LV trait studied | ||||
4B. Associations of ETT traits | |||||
Candidate Gene | FHS 100K SNP | Physical Position | Trait | GEE p-value | FBAT p-value |
ACE | rs10491167 | 58780430 | Stage 2 Exercise systolic blood pressure | 0.046 | 0.137 |
 | rs10491168 | 58795195 | Stage 2 Exercise systolic blood pressure | 0.030 | 0.124 |
 | rs721575 | 59136652 | Post-exercise 3 minute recovery heart rate | 0.024 | 0.025 |
ADRB1 | rs2419857 | 115607366 | Stage 2 Exercise heart rate | 0.852 | 0.030 |
 | rs4345919 | 115651155 | Post-exercise 3 minute recovery heart rate | 0.048 | 0.740 |
AGT | rs1752189 | 227000046 | Post-exercise 3 minute recovery SBP | 0.145 | 0.021 |
 | rs758216 | 227005969 | Post-exercise 3 minute recovery SBP | 0.184 | 0.050 |
 | rs10495298 | 227120049 | Stage 2 Exercise systolic blood pressure | 0.288 | 0.050 |
 | rs2478516 | 227175387 | Stage 2 Exercise systolic blood pressure | 0.021 | 0.486 |
AGTR1 | rs275678 | 149851039 | Post-exercise 3 minute recovery SBP | 0.216 | 0.049 |
 | rs427832 | 149949061 | Post-exercise 3 minute recovery SBP | 0.014 | 0.171 |
 | rs1949350 | 150089423 | Stage 2 Exercise heart rate | 0.010 | 0.335 |
VEGF | rs729761 | 43912549 | Stage 2 Exercise heart rate | 0.041 | 0.035 |
NOS3 | rs2303928 | 150176978 | Stage 2 Exercise heart rate | 0.012 | 0.056 |
4C. Associations of BA function traits | |||||
Candidate Gene | FHS 100K SNP | Physical Position | Trait | GEE p-value | FBAT p-value |
ACE | no SNP was associated with a p value < 0.05 | ||||
ADRB1 | rs180940 | 115712401 | BA hyperemic flow velocity | 0.581 | 0.015 |
 | rs180935 | 115720249 | BA hyperemic flow velocity | 0.953 | 0.030 |
 | rs180934 | 115720720 | BA hyperemic flow velocity | 0.662 | 0.029 |
 | rs10509999 | 115917269 | BA hyperemic flow velocity | 0.001 | 0.137 |
 | rs10510000 | 115961985 | BA hyperemic flow velocity | 0.007 | 0.014 |
 | rs10510001 | 115962372 | BA hyperemic flow velocity | 0.017 | 0.239 |
AGT | rs758216 | 227005969 | Baseline BA flow velocity | 0.049 | 0.488 |
 | rs1202585 | 227309949 | Baseline BA diameter | 0.002 | 0.080 |
 | rs1202585 | 227309949 | BA hyperemic flow velocity | 0.049 | 0.080 |
AGTR1 | rs1492090 | 149884751 | BA hyperemic flow velocity | 0.026 | 0.293 |
 | rs427832 | 149949061 | Baseline BA flow velocity | 0.509 | 0.043 |
VEGF | rs833048 | 43762514 | BA hyperemic flow velocity | 0.860 | 0.036 |
 | rs10498756 | 44046909 | BA hyperemic flow velocity | 0.312 | 0.008 |
NOS3 | rs741067 | 149938103 | Baseline BA diameter | 0.043 | 0.024 |
 | rs1006581 | 149949571 | Baseline BA diameter | 0.009 | 0.097 |
 | rs2215564 | 150001612 | BA hyperemic flow velocity | 0.028 | 0.104 |