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Table 1 Lipid Phenotypes Examined Using Affymetrix 100K GeneChip Scan

From: A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

Phenotype

Acronym

Phenotypes

N

h2 *

Offspring Exam

Adjustment† Multivariable model

Total cholesterol

TC

7

1069

0.57‡

1,2,3,4,5,6,7

Age, age2, smoking, body mass index, alcohol consumption, menopausal status, hormone replacement therapy; Covariate-adjusted residuals created separately by gender

Low-density lipoprotein cholesterol

LDL-C

7

1056

0.59‡

1,2,3,4,5,6,7

 

High-density lipoprotein cholesterol

HDL-C

7

1062

0.52‡

1,2,3,4,5,6,7

 

Triglycerides

TG

7

1068

0.48‡

1,2,3,4,5,6,7

 

Mean total cholesterol

MeanTC

1

1087

0.61

Avg of Exams 1,2,3,4,5,6,7

 

Mean low-density lipoprotein cholesterol

MeanLDL-C

1

1086

0.66

Avg of Exams 1,2,3,4,5,6,7

 

Mean high-density lipoprotein cholesterol

MeanHDL-C

1

1087

0.69

Avg of Exams 1,2,3,4,5,6,7

 

Mean triglycerides

MeanTG

1

1087

0.58

Avg of Exams 1,2,3,4,5,6,7

 

Apolipoprotein A-I

ApoA-I

1

997

0.42

4

 

Apolipoprotein B

ApoB

1

997

0.47

4

 

Apolipoprotein C3

ApoC3

1

767

0.38

4

 

Apolipoprotein E

ApoE

1

744

0.54

5

 

High-density lipoprotein 2 cholesterol

HDL2-C

2

955 (exam 4) 958 (exam 5)

0.50 0.53

4,5

 

High-density lipoprotein 3 cholesterol

HDL3-C

2

984 (exam 4) 1020 (exam 5)

0.48 0.54

4,5

 

Large high-density lipoprotein by NMR

HDLNMRlg

1

851

0.53

4

 

Intermediate high-density lipoprotein by NMR

HDLNMRint

1

851

0.22

4

 

Small high-density lipoprotein by NMR

HDLNMRsm

1

851

0.24

4

 

High-density lipoprotein particle size by NMR

HDLNMRsz

1

851

0.50

4

 

Intermediate-density lipoprotein particle by NMR

IDLNMR

1

851

0.20

4

 

Large low-density lipoprotein by NMR

LDLNMRlg

1

851

0.39

4

 

Small low-density lipoprotein by NMR

LDLNMRsm

1

851

0.40

4

 

Low-density lipoprotein particle size by NMR

LDLNMRsz

1

851

0.40

4

 

Large very low-density lipoprotein particle by NMR

VLDLNMRlg

1

851

0.34

4

 

Intermediate very low-density lipoprotein particle by NMR

VLDLNMRint

1

878

0.40

4

 

Small very low-density lipoprotein particle by NMR

VLDLNMRsm

1

851

0.24

4

 

Very low-density lipoprotein particle size by NMR

VLDLNMRsz

1

851

0.42

4

 

Triglyceride/high-density lipoprotein cholesterol ratio

tghdl

7

1060

0.56‡

1,2,3,4,5,6,7

 

Total cholesterol/high-density lipoprotein cholesterol ratio

cholhdl

7

1060

0.58‡

1,2,3,4,5,6,7

 

Lipoprotein(a)

Lp(a)

1

763

0.90

3

 

Remnant lipoprotein cholesterol

RLP-C

1

746

0.34

4

 

Remnant lipoprotein triglycerides

RLP-TG

1

715

0.33

4

 
  1. Note: TG, MeanTG, cholhdl, and tghdl were natural log transformed due to skewed distribution;
  2. *Heritability (h2) estimates presented are those after multivariable-adjustment; P < 0.0001 for all heritability estimates.
  3. †Each phenotype had 2 adjustment schemes: age- and sex-adjusted and multivariable-adjusted. Both age- and sex-adjusted and multivariable-adjusted model results are web posted.
  4. ‡Heritability estimates were derived from lipid phenotypes at a single time-point, that of FHS Examination 1.
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BMC Medical Genetics

ISSN: 1471-2350

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