|  |  | Exam cycle(s) |  | |
---|---|---|---|---|---|
Phenotype Subgroup • Trait (variable name on the website*) | Number of Traits | N (MV**) | Offspring / Original Cohort |  | Adjustment |
Survival Traits: Cox regression | |||||
Survival • Age at death (1. deathageX, 2. deathageMV) | 2 | 1345 (1166) | Cohort & Offspring pooled |  | Cox regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1 |
Categorical traits: Logistic regression | |||||
• Survival past the ALE (1. deathpastALEX, 2. deathpastALEMV) | 2 | 1345 (1166) | Cohort & Offspring pooled |  | Logistic regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, smoking, obesity (BMI ≥ 30), CVD risk factors, co-morbidity measured at exam 1 |
Morbidity-free survival (free of CVD, cancer and dementia) • At age 65 years (1. morbidityfree65X, 2. morbidityfree65MVX) | 2 | 558 (558) | Cohort & Offspring pooled, exams closest to age 65 years |  | Logistic regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, smoking, obesity, CVD risk factors measured at exam closest to age 65 years (within a 5 year horizon) |
Quantitative Traits: Linear regression | |||||
Reproductive Aging • Age at natural menopause (1. menoageX, 2. menoageMVX) | 2 | 438 (378) | Cohort & Offspring pooled, women only |  | Linear regression 1. crude 2. multivariable adjusted for smoking, BMI, parity, generation (measured at exams prior to menopause) |
Cognitive function • MMSE at age 65 years (1. MMSE65X, 2. MMSE65MVX) • MMSE at the specified Offspring exam (1. MMSE5X, 2. MMSE5MVX, 1. MMSE7X, 2. MMSE7MV, 1. MMSE5to7X, 2. MMSE5to7MVX) | 2 | 593 (462) | Cohort & Offspring pooled, exams at age 65 |  | Linear regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, FSRP measured at exam closest to age 65 years (5 year horizon) |
 | 6 | 1038 (913) | Exam 5 Exam 7 Exam 5 & 7 average score |  | Linear regression Sex-specific 1. birth cohort 2. multivariable adjusted for birth cohort, education, FSRP; covariates measured at the specified exam |
Physical Performance • Hand grip (2. handgrip7x, 2. handgrips727x) • Walking speed (2. walkingspeed7x, 2. walkingspeed727x) | 6 | 764 | Exam 7 Exam 7 and Exam 27 |  | Linear regression Sex-specific‡ 1. age 2. multivariable adjusted for age, height, weight at the specified exam |
Biologic Age by Osseographic Scoring System (1. deltaOSSr, delta OSSrf, deltaOSSrm) | 3 | 714 | Offspring and Cohort pooled exam 6/7 and exam 22 |  | Linear regression Sex- and cohort-specific ranked residuals§ 1. multivariable adjusted for age, height, BMI, menopause, estrogen use |