Skip to main content

Table 1 Types of traits phenotype master trait table, exam cycle, numbers of participants in family plates with phenotype

From: Genome-wide association with select biomarker traits in the Framingham Heart Study

Phenotype

Acronym

Trait N = 27*

Subject N

Offspring Exam

Adjustment* Multivariable model

Inflammation/Oxidative Stress

CD40 Ligand, serum & plasma

CD40L

2

998

7

Age, sex, smoking, systolic and diastolic blood pressure, hypertension treatment, body mass index, waist circumference, Total/HDL cholesterol, triglyceride, lipid lowering medication, glucose, diabetes, aspirin, hormone replacement therapy and prevalent cardiovascular disease

C-reactive protein

CRP

5

980–1008

2, 5, 6, 7; Average: 2, 6, 7

 

Intercellular adhesion molecule-1

ICAM1

1

1006

7

 

Interleukin-6

IL6

1

1006

  

Urinary isoprostanes/creatinine

IsoCrUrine

1

828

  

Monocyte chemoattractant protein-1

MCP1

1

989

  

Myeloperoxidase

MPO

1

974

  

Osteoprotegerin

OPG

1

1005

  

P-selectin

Pselectin

1

1007

  

Tumor necrosis factor alpha

TNFA

1

753

  

Tumor necrosis factor receptor-2

TNFRII

1

980

  

Natriuretic Peptides

N-terminal pro-atrial natriuretic peptide

ANP

1

938

6

Age, sex, BMI, SBP, HTN Rx, LDL Total/HDL, diabetes, LV mass, LA size, CVD

B-type natriuretic peptide

BNP

1

938

  

Liver Function

Bilirubin

Bili

1

910

2

Age, sex, BMI, HDL, HTN, diabetes, serum total protein, alcohol intake, TG, & smoking

Aspartate aminotransferase **

AST

1

904

  

Alanine aminotransferase

ALT

1

904

  

Alkaline phosphatase

AlkPhos

1

904

  

Gamma-glutamyl transferase

GGT

1

896

  

Vitamins

Vitamin K plasma phylloquinone

VitKPhylloq

1

518

6/7†

Age, sex, SBP, DBP, BMI, waist, total/HDL, smoking, glucose, TG, diabetes, HTN Rx, lipid lowering Rx, hormone replacement Rx, asthma Rx, alcohol use, prevalent CVD

Vitamin K percentage of undercarboxylated osteocalcin

VitKPucOC

1

504

  

Vitamin D plasma 25(OH)-D

VitD25OH

1

517

  
  1. *Each trait had 2 adjustment schemes web posted: age- and sex-adjusted, and multivariable-adjusted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007. GEE and FBAT traits are web displayed pha001115 through pha001218; Linkage traits are located from pha002301 through pha002352. In the present manuscript we examine the multivariable-adjusted trait, which we count as 1 trait. Note: biomarkers were natural log transformed due to skewed distribution; **normalized deviates. †Vitamin measurements straddled exams 6 & 7, covariates from same exam biomarker assayed. SBP, DBP = systolic and diastolic blood pressure, HTN Rx = hypertension treatment, BMI = body mass index, TC/HDL = total/high density lipoprotein cholesterol; TG = triglyceride, HRT = hormone replacement therapy, Rx = medication therapy, CVD = cardiovascular disease; LDL = low density lipoprotein; LV mass = left ventricular mass; LA size = left atrial size; Atrial natriuretic peptide = N-terminal pro-atrial natriuretic peptide.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us