Table 1 Inclusion and exclusion criteria for probands in the FISSIC program

a Inclusion criteria

1. Diagnosis of at least one ischemic stroke confirmed by the study neurologist on the basis of history, medical records, and head imaging by CT or MRI;

2. At least 18 years old by the time of enrolment in the study;

3. At least one full sibling or parent alive in areas nearby;

4. Written informed consent by the patient or surrogate.

b Exclusion criteria

1. Diagnosis of TIA only;

2. Diagnosis of vasospasm after subarachnoid hemorrhage;

3. Diagnosis of some Mendelian disorders: CADASIL, Fabry disease, MELAS, or sickle cell anaemia;

4. Diagnosis of iatrogenic ischemic stroke associated with a surgical/interventional procedure such as coronary artery bypass grafting, carotid endarterectomy, or heart valve surgery;

5. Diagnosis of ischemic stroke associated with autoimmune condition or endocarditis.