Allele, haplotypec | Nucleotide/amino acidd | Estimated Frequency Distributione% (95% CI) | Persistent Cough OR (95% CI) | Wheeze OR (95% CI) | ||||
---|---|---|---|---|---|---|---|---|
SFTPA1 | aa 19 | aa 50 | aa 62 | aa 133 | aa 219 | Â | Â | Â |
   6A | C/Ala | C/Leu | G | G | C/Arg | 6.1% (4.0 – 8.3) | 3.69 (1.71, 7.98) | 4.72 (2.20, 10.11) |
   6A 2 | T/Val | G/Val | A | A | C/Arg | 54.0% (49.3 – 58.7) | 1.18 (0.63, 2.19) | 1.13 (0.60, 2.14) |
   6A 3 | T/Val | C/Leu | A | A | C/Arg | 25.6% (21.6 – 29.6) | 0.81 (0.49, 1.36) | 0.83 (0.49, 1.40) |
   6A 4 | T/Val | C/Leu | G | A | T/Trp | 6.2% (4.1 – 8.4) | 0.94 (0.44, 2.03) | 0.70 (0.31, 1.60) |
   all others |  |  |  |  |  | 8% |  |  |
SFTPA2 | aa 9 | aa 91 | aa 140 | aa 223 | Â | Â | Â | Â |
   1A | C/Thr | C/Pro | C | C/Gln |  | 8.4% (6.0 – 10.8) | 1.53 (0.75, 3.14) | 1.30 (0.63, 2.71) |
   1A 0 | A/Asn | G/Ala | C | C/Gln |  | 54.2% (49.5 – 58.8) | 1.13 (0.60, 2.13) | 1.14 (0.59, 2.19) |
   1A 1 | C/Thr | G/Ala | T | A/Lys |  | 13.7% (10.7 – 16.7) | 0.82 (0.45, 1.48) | 0.87 (0.47, 1.58) |
   1A 2 | C/Thr | G/Ala | C | C/Gln |  | 10.2% (7.6 – 12.7) | 0.95 (0.49, 1.84) | 0.83 (0.42, 1.64) |
   1A 3 | A/Asn | G/Ala | T | A/Lys |  | 1.8% (0.7 – 2.9) | 0.45 (0.08, 2.48) | 0.55 (0.10, 3.06) |
   1A 5 | C/Thr | C/Pro | T | C/Gln |  | 4.6% (2.7 – 6.5) | 0.43 (0.15, 1.23) | 0.66 (0.24, 1.79) |
   1A 6 | C/Thr | G/Ala | T | C/Gln |  | 3.2% (1.7 – 4.7) | 1.41 (0.49, 4.05) | 1.54 (0.54, 4.39) |
   all others |  |  |  |  |  | 4% |  |  |
SFTPA Haplotype | Â | Â | Â | Â | Â | Â | Â | Â |
   6A/1A |  |  |  |  |  | 5.4% (3.2 – 7.2) | 3.20 (1.39, 7.36) | 3.25 (1.43, 7.37) |
   6A 2 /1A 0 |  |  |  |  |  | 49.0% (44.4 – 53.6) | 1.20 (0.66, 2.19) | 1.04 (0.57, 1.90) |
   6A 2 /1A 2 |  |  |  |  |  | 1.8% (0.6 – 2.9) | 1.43 (0.36, 5.70) | 0.26 (0.03, 1.99) |
   6A 2 /1A 3 |  |  |  |  |  | 1.0% (0.2 – 1.9) | 0.65 (0.10, 4.39) | 0.79 (0.11, 5.47) |
   6A 3 /1A 0 |  |  |  |  |  | 4.7% (2.8 – 6.6) | 1.16 (0.49, 2.74) | 0.92 (0.37, 2.31) |
   6A 3 /1A 1 |  |  |  |  |  | 11.3% (8.5 – 14.1) | 1.12 (0.60, 2.08) | 1.08 (0.57, 2.04) |
   6A 3 /1A 2 |  |  |  |  |  | 5.6% (3.6 – 7.6) | 0.93 (0.40, 2.16) | 0.92 (0.39, 2.17) |
   6A 3 /1A 6 |  |  |  |  |  | 1.7% (0.5 – 2.8) | 0.91 (0.21, 4.07) | 2.26 (0.55, 9.33) |
   6A 4 /1A 5 |  |  |  |  |  | 2.9% (1.4 – 4.4) | 0.28 (0.07, 1.07) | 0.30 (0.08, 1.20) |
   6A 4 /1A 6 |  |  |  |  |  | 1.8% (0.6 – 3.0) | 1.88 (0.49, 7.16) | 1.69 (0.44, 6.39) |
   Others |  |  |  |  |  | 14.9% |  |  |