Figure 2

Relationships amongst pre/post-intervention quantities. Graph showing conditional dependencies of pre/post-intervention quantities. Γ contains the carrier status of each family member γ _i . The factors affecting each member's choice of age of intervention I _i are pre-intervention disease history Y _i , C _i , genetic test results x _test , pre-intervention censoring age U _i , and everyone else's family history H _-i . Post-intervention disease history is $Y_i^I$, $C_i^I$ and age last known alive $U_i^I$. For simplicity, auxiliaries x _i are not shown.