Figure 7
From: Rubinstein-Taybi Syndrome: spectrum of CREBBP mutations in Italian patients
Nuclear Localization signals (NLSs) predicted by PSORTII [21] analysis. a wild-type CREBBP with three putative NLSs (two monopartite and one bipartite) evidenced by squares: the affected Arg14 is marked in red; b Mutated CREBBP of patient 23 with Arg14Gly substitution with only one predicted NLS. The bottom panels show the cellular localization predictions of wt and mutated proteins.