Table 4 Pooled differences (95% CI) in body mass index (kg/m2) between individuals homozygous and heterozygous carriers of the 363S allele of the GRL gene and homozygotes for the N363 allele. Fixed effects model
Studies | Difference in BMI (kg/m2) Pooled estimates | 95% CI | Q statistic | k | p# |
|---|---|---|---|---|---|
Overall studies | +0.18 | +0.004 to +0.35* | 84.47 | 21 | <0.0001 |
BMI < 27 kg/m2 | +0.14 | -0.052 to +0.32 | 29.15 | 10 | 0.0006 |
BMI > 27 kg/m2 | +0.37 | -0.047 to +0.79 | 54.31 | 11 | <0.0001 |
Adults (>25 years) | +0.51 | +0.31 to +0.72* | 27.47 | 16 | 0.0252 |
Children and adolescents (<25 years) | -0.67 | -0.99 to -0.35* | 19.94 | 5 | 0.0005 |
- Ethnicity | |||||
European Countries | +0.16 | -0.01 to +0.34 | 74.84 | 15 | <0.0001 |
Australia | +0.45 | -0.34 to +1.24 | 9.03 | 5 | 0.06 |
- Gender | |||||
Men | -0.37 | -1.25 to +0.51 | 1.20 | 3 | 0.5487 |
Men and women | +0.20 | +0.02 to +0.37 | 81.76 | 18 | <0.0001 |
- Mutation prevalence | |||||
(<5%) | -0.54 | -0.96 to -0.12 | 20.69 | 6 | 0.0009 |
(5–10%) | +0.34 | +0.15 to +0.54 | 37.74 | 9 | <0.0001 |
(>10%) | +0.10 | -0.57 to +0.77 | 11.84 | 6 | 0.037 |
One population | |||||
BMI < 27 kg/m2 | +0.41 | +0.17 to +0.66* | 5.88 | 4 | 0.1177 |
BMI ≥ 27 kg/m2 | +1.19 | +0.64 to +1.74* | 13.34 | 5 | 0.0097 |
Normal weight subjects | |||||
already published data | +0.56 | -0.07 to +1.19 | 1.04 | 3 | 0.5941 |
novel data | -0.50 | -0.84 to -0.17* | 1.72 | 3 | 0.4227 |
Obese subjects | |||||
already published data | +0.32 | -0.82 to +1.46 | 0.07 | 3 | 0.9633 |
novel data | -1.26 | -2.10 to -0.49* | 15.77 | 3 | <0.001 |