Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1)and association with bipolar affective disorder in Taiwan

Table 5 Haplotype frequency and test statistics between cases and controls using htSNPs.

Haplotypes from htSNPs^a	Represented haplotypes from 10 SNPs^a	Patient (frequency)	Normal	Fisher's Exact Test (Pvalue)^b	OR^a,c	95% CI^c
TAG	TAGTAAGACA TAGTAAGATA	0.365	0.369	1.000	0.983	0.66–1.47
TGC	TAGAGACCTG TAGTGACCTG TAGTGACATG	0.185	0.169	0.699	1.109	0.66–1.85
GGC	GGTTGCCCTA GGGAGACCCA GGTTGCCCTG GGTAGACCCA	0.155	0.102	0.137	1.616	0.89–2.92
TAC	TAGTAACACA TAGTAACCTG	0.030	0.039	0.787	0.765	0.26–2.25
TGG	TAGCGCGACA	0.025	0.015	0.498	1.735	0.41–7.36
Others		0.240	0.306	0.149	0.717	0.46–1.11
Total				0.446

a. SNPs in bold and dark color are htSNPs selected from common haplotypes using the SNPtagger program.
b. Chi-square, Fisher's Exact Test and Odds Ratio were calculated by using the SAS program.
c. OR: odds Ratio; CI: confidence Interval.

ISSN: 1471-2350