HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Table 6 Serum Immunoglobulin Concentrations in Index Patients with Significantly Associated HLA-A and -B Haplotypes.¹

Number of Significantly Associated Haplotypes	0	1	2
Serum IgG, mg/dL (n)	734 ± 273 (45)	735 ± 287 (112)	749 ± 257 (33)
Serum IgA, mg/dL (n)	167 ± 92 (48)	157 ± 117 (109)	169 ± 71 (33)
Serum IgM, mg/dL (n)	108 ± 70 (46)	116 ± 96 (110)	115 ± 108 (34)

¹ These data are expressed as mean ± 1 SD. Significantly associated haplotypes were defined as those that occurred with significantly greater frequency in CVID and IgGSD index cases than in control subjects. These six haplotypes were: A*01-B*08, A*02-B*44, A*03-B*07, A*03-B*14, A*31-B*40, and A*32-B*14 (see Table 4). There were no significant differences in the mean values of IgG, IgA, or IgM in the index patients grouped by inheritance of significantly associated haplotypes.

ISSN: 1471-2350