HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Table 2 Phenotype Frequencies of HLA-A Alleles in Alabama Subjects.¹

A* Phenotypes	Frequency in CVID and IgGSD Index Patients (n= 240)	Frequency in Control Subjects (n)	Significant Uncorrected Values of p	Significant Corrected Values of p ²
01	0.3458	0.3397 (1,319)
02	0.5292	0.5206 (1,310)
03	0.2875	0.2739 (1,318)
11	0.075	0.1136 (1,320)
23	0.0500	0.0375 (1,254)
24	0.300	0.1304 (1,265)	< 0.0001	< 0.0016
25	0.0333	0.0297 (1,281)
26	0.0500	0.0634 (1,278)
28	0.025	0.0773 (1,320)
29	0.0583	0.0620 (1,290)
30	0.0292	0.0405 (1,308)
31	0.0542	0.0350 (1,258)
32	0.0375	0.0536 (1,232)
33	0.0083	0.0176 (1,248)
34	0.0083	0.0044 (1,146)
66	0.0167	0 (243)

¹ Phenotypes were detected using low-resolution DNA-based typing in CVID and IgGSD index patients and microlymphocytotoxcity typing in control subjects. Because our HLA typing was conducted over a period of several years during which splits of certain alleles had not been defined, we collapsed the phenotype HLA-A*10 into HLA-A*26 and the phenotype HLA-A*68 into HLA-A*28 to facilitate the present comparisons. ²These values were corrected using the Bonferroni inequality method.

ISSN: 1471-2350