Table 1 Characteristics of studies included in the meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism and glaucoma *
Author/Year [Reference] | Ethnicity | Sample size (Case/control) | Glaucoma type | Number of cases | Number of controls | HWE P-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|
ε2 | ε3 | ε4 | ε2 | ε3 | ε4 | |||||
Krumbiegel 2010 [11] | Caucasian (German) | 801(459/342) | PEXG | 79 | 740 | 99 | 51 | 547 | 86 | 0.926 |
Krumbiegel 2010 [11] | Caucasian (Italian) | 323(133/190) | PEXG | 21 | 222 | 23 | 23 | 317 | 40 | 0.024 |
Saglar 2009 [12] | Caucasian | 194(75/119) | POAG | 13 | 126 | 11 | 10 | 204 | 24 | 0.832 |
Al-Dabbagh 2009 [13] | Asian | 230(100/130) | POAG,PACG | 0 | 181 | 19 | 0 | 249 | 11 | 0.969 |
Jia 2009 [14] | Asian | 376(176/200) | POAG | 34 | 278 | 40 | 35 | 329 | 36 | 0.897 |
Yuan 2007 [15] | Asian | 162(105/57) | POAG,PACG | 48 | 81 | 81 | 18 | 76 | 20 | <0.0001 |
Zetterberg 2007 [16] | Caucasian | 429(242/187) | POAG | 50 | 376 | 58 | 42 | 289 | 43 | 0.923 |
Hu 2007 [17] | Asian | 219(142/77) | POAG | 17 | 229 | 38 | 11 | 129 | 14 | 0.409 |
Tamura 2006 [18] | Asian | 105(28/77) | POAG | 3 | 42 | 11 | 12 | 135 | 7 | 0.079 |
Lam 2006 [19] | Asian | 700(400/300) | POAG | 79 | 674 | 47 | 50 | 495 | 55 | 0.065 |
Mabuchi 2005 [20] | Asian | 489(310/179) | POAG | 16 | 567 | 37 | 18 | 302 | 38 | 0.104 |
Jünemann 2004 [21] | Caucasian | 128(96/32) | POAG | 19 | 146 | 27 | 9 | 40 | 15 | 0.012 |
Lake 2004 [22] | Caucasian | 504(155/349) | POAG | 28 | 229 | 53 | 56 | 534 | 108 | 0.316 |
Ressiniotis 2004 [23] | Caucasian | 212(137/75) | POAG | 35 | 199 | 40 | 16 | 114 | 20 | NA# |
Vickers 2002 [24] | Caucasian | 193(142/51) | POAG | 27 | 206 | 51 | 15 | 75 | 12 | 0.202 |