From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study
CFTRgroup | Variable | Polymorphism | Genotype | N | Mean | SD | SEM | p- value corrected |
---|---|---|---|---|---|---|---|---|
Without taking CFTR mutation into account | Bhalla scorea | GCLC-3506A > G | AA | 94 | 19.70 | 6.007 | 0.620 | 0.044 |
AG + GG | 43 | 17.00 | 5.033 | 0.768 | ||||
No mutation identified | SpO2a | GSTT1 deletion | Not expressed | 15 | 96.13 | 2.232 | 0.576 | 0.048 |
Expressed | 29 | 93.17 | 5.245 | 0.974 | ||||
Bhalla scoreb | GSTM1/GSTT1 deletions | −/− | 4 | 14.75 | 1.258 | 0.629 | 0.02 | |
+/− and −/+ | 21 | 6.900 | 6.610 | 1.442 | ||||
+/+ | 9 | 15.33 | 7.533 | 2.511 |