From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study
CFTRgroup | Polymorphism | Genotype | Variable | pc | OR | CI (5–95%) | ||
---|---|---|---|---|---|---|---|---|
One CFTR mutation identified | GCLC-129C > T | PAM | ||||||
Presence | Absence | Total | ||||||
CC | 25 | 17 | 42 | 0.044 | 11.27 | 1.6–272.6 | ||
CT + TT | 1 | 8 | 9 | - | - | |||
GCLC-3506A > G | PANM | |||||||
Presence | Absence | Total | ||||||
AA | 28 | 9 | 37 | 0.012 | 7.408 | 1.905–33.43 | ||
AG + GG | 4 | 10 | 14 | - | - | |||
No mutation identified | GSTT1 gene deletion | PANM | ||||||
Presence | Absence | Total | ||||||
Not expressed | 13 | 9 | 21 | 0.008 | 7.895 | 2.095–34.96 | ||
Expressed | 4 | 23 | 27 | - | - | |||
One CFTR mutation identified + IP | GSTM1 gene deletion | Digestive symptoms | ||||||
< 6 months | ≥ 6 months | |||||||
Not expressed | 3 | 12 | 15 | 0.032 | 0.134 | 0.023-0.606 | ||
Expressed | 14 | 7 | 21 | - | - | |||
Two mutations identified | GSTP1 + 313A > G | Osteoporosis | ||||||
Presence | Absence | Total | ||||||
AA | 2 | 42 | 44 | 0.036 | 0.141 | 0.028–0.687 | ||
AG + GG | 9 | 26 | 35 | - | - | |||
Without taking CFTR mutation into account | Age (months) | |||||||
≤ 154 | > 154 | Total | ||||||
AA | 58 | 39 | 97 | 0.044 | 2.198 | 1.208–4.037 | ||
AG + GG | 33 | 49 | 82 | - | - |