From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study
Variable | Without taking CFTRmutation into account | No CFTRmutations identified | No CFTRmutations identified with PI | One identified CFTRmutation | One identified CFTRmutation with PI | Two identified CFTRmutations | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | |
Gendera | 0.036 | 0.144 | 0.943 | 1 | 0.601 | 1 | 0.369 | 1 | 0.114 | 0.456 | 0.014 | 0.056 |
Agea | 0.331 | 1 | 0.647 | 1 | 0.496 | 1 | 0.054 | 0.216 | 0.149 | 0.596 | 0.908 | 1 |
Onset of symptomsa | 0.300 | 1 | 0.996 | 1 | 0.835 | 1 | 0.579 | 1 | 0.854 | 1 | 0.049 | 0.196 |
Onset of pulmonary diseasea | 0.588 | 1 | 0.359 | 1 | 0.431 | 1 | 0.776 | 1 | 0.267 | 1 | 0.559 | 1 |
Onset of digestive diseasea | 0.626 | 1 | 0.480 | 1 | 0.581 | 1 | 0.433 | 1 | 0.458 | 1 | 0.051 | 0.204 |
Diagnosisa | 0.520 | 1 | 0.207 | 0.828 | 0.490 | 1 | 0.710 | 1 | 0.510 | 1 | 0.992 | 1 |
BMIa | 0.283 | 1 | 0.954 | 1 | 0.717 | 1 | 0.252 | 1 | 0.998 | 1 | 0.596 | 1 |
Bhalla scoreb | 0.088 | 0.352 | 0.005 | 0.02 | 0.915 | 1 | 0.381 | 1 | 0.218 | 0.872 | 0.481 | 1 |
Kanga scoreb | 0.885 | 1 | 0.443 | 1 | 0.216 | 0.864 | 0.912 | 1 | 0.261 | 1 | 0.455 | 1 |
Shwachman-Kulczycki scoreb | 0.627 | 1 | 0.144 | 0.576 | 0.087 | 0.348 | 0.387 | 1 | 0.104 | 0.416 | 0.195 | 0.780 |
Nasal polyposisa | 0.098 | 0.392 | 0.483 | 1 | 0.699 | 1 | 0.467 | 1 | 0.362 | 1 | 0.102 | 0.408 |
Diabetes mellitusa | 0.259 | 1 | 0.240 | 0.96 | 0.790 | 1 | 0.992 | 1 | 0.555 | 1 | 0.334 | 1 |
Osteoporosisa | 0.204 | 0.816 | 0.501 | 1 | 0.525 | 1 | 0.427 | 1 | 0.187 | 0.748 | 0.386 | 1 |
Meconium ileus | 0.683 | 1 | 0.266 | 1 | 0.348 | 1 | 0.517 | 1 | 0.905 | 1 | 0.626 | 1 |
Pancreatic insufficiencya | 0.965 | 1 | 0.791 | 1 | - | - | 0.975 | 1 | - | - | 0.653 | 1 |
SpO2b | 0.449 | 1 | 0.021 | 0.084 | 0.557 | 1 | 0.616 | 1 | 0.774 | 1 | 0.786 | 1 |
FVC(%)b | 0.576 | 1 | 0.518 | 1 | 0.859 | 1 | 0.928 | 1 | 0.475 | 1 | 0.758 | 1 |
FEV1(%)b | 0.778 | 1 | 0.182 | 0.728 | 0.977 | 1 | 0.799 | 1 | 0.827 | 1 | 0.657 | 1 |
FEV1/FVCb | 0.178 | 1 | 0.007 | 0.028 | 0.265 | 1 | 0.789 | 1 | 0.395 | 1 | 0.593 | 1 |
FEF25–75%b | 0.881 | 1 | 0.014 | 0.056 | 0.751 | 1 | 0.719 | 1 | 0.370 | 1 | 0.382 | 1 |
First P. aeruginosa a | 0.545 | 1 | 0.686 | 1 | 0.295 | 1 | 0.019 | 0.076 | 0.299 | 1 | 0.123 | 0.492 |
P. aeruginosa mucoida | 0.134 | 0.536 | 0.118 | 0.472 | 0.492 | 1 | 0.575 | 1 | 0.940 | 1 | 0.337 | 1 |
P. aeruginosa no mucoida | 0.487 | 1 | 0.051 | 0.204 | 0.682 | 1 | 0.167 | 0.668 | 0.190 | 0.760 | 0.847 | 1 |
A. xylosoxidans a | 0.541 | 1 | 0.779 | 1 | 0.663 | 1 | 0.079 | 1 | 0.537 | 1 | 0.995 | 1 |
S. aureus a | 0.660 | 1 | 0.243 | 0.972 | 0.839 | 1 | 0.716 | 1 | 0.181 | 0.724 | 0.667 | 1 |
B. cepacia a | 0.861 | 1 | 0.142 | 0.568 | 0.054 | 1 | 0.759 | 1 | 0.145 | 0.580 | 0.640 | 1 |