From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study
Variable | Without taking CFTRmutation into account | No CFTRmutations identified | No CFTRmutations identified with PI | One identified CFTRmutation | One identified CFTRmutation with PI | Two identified CFTRmutations | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | |
Gendera | 0.171 | 0.684 | 0.764 | 1 | 0.075 | 0.300 | 0.267 | 1 | 0.537 | 1 | 0.110 | 0.440 |
Agea | 1 | 1 | 0.498 | 1 | 0.736 | 1 | 0.579 | 1 | 1 | 1 | 1 | 1 |
Onset of symptomsa | 0.268 | 1 | 0.459 | 1 | 0.721 | 1 | 1 | 1 | 1 | 1 | 0.629 | 1 |
Onset of pulmonary diseasea | 0.424 | 1 | 0.068 | 0.272 | 1 | 1 | 1 | 1 | 0.742 | 1 | 0.639 | 1 |
Onset of digestive diseasea | 0.409 | 1 | 0.665 | 1 | 1 | 1 | 1 | 1 | 0.008 | 0.032 | 0.635 | 1 |
Diagnosisa | 1 | 1 | 0.059 | 0.236 | 0.729 | 1 | 0.149 | 0.596 | 1 | 1 | 1 | |
BMIa | 0.462 | 1 | 0.503 | 1 | 0.115 | 0.460 | 0.725 | 1 | 1 | 1 | 0.169 | 0.676 |
Bhalla scoreb | 0.86 | 1 | 0.11 | 0.44 | 0.059 | 0.236 | 0.050 | 0.200 | 0.692 | 1 | 0.879 | 1 |
Kanga scoreb | 0.982 | 1 | 0.693 | 1 | 0.367 | 1 | 0.822 | 1 | 0.480 | 1 | 0.784 | 1 |
Shwachman-Kulczycki scoreb | 0.501 | 1 | 0.449 | 1 | 0.884 | 1 | 0.123 | 0.492 | 0.777 | 1 | 0.568 | 1 |
Nasal polyposisa | 0.331 | 1 | 0.136 | 0.544 | 0.610 | 1 | 1 | 1 | 0.407 | 1 | 0.765 | 1 |
Diabetes mellitusa | 0.560 | 1 | 1 | 1 | 1 | 1 | 0.703 | 1 | 1 | 1 | 0.169 | 0.676 |
Osteoporosisa | 0.217 | 0.868 | 0.435 | 1 | 0.377 | 1 | 0.173 | 0.633 | 1 | 1 | 1 | |
Meconium ileus | 1 | 1 | 1 | 1 | 0.640 | 1 | 0.726 | 1 | 1 | 1 | 0.776 | 1 |
Pancreatic insufficiencya | 1 | 1 | 0.765 | 1 | - | - | 1 | 1 | - | - | 1 | 1 |
SpO2b | 0.187 | 0.748 | 0.012 | 0.048 | 0.500 | 1 | 0.780 | 1 | 0.652 | 1 | 0.645 | 1 |
FVC(%)b | 0.990 | 1 | 0.741 | 1 | 0.020 | 0.08 | 0.538 | 1 | 0.307 | 1 | 0.967 | 1 |
FEV1(%)b | 0.827 | 1 | 0.623 | 1 | 0.030 | 0.012 | 0.786 | 1 | 0.972 | 1 | 0.943 | 1 |
FEV1/FVCb | 0.915 | 1 | 0.749 | 1 | 0.532 | 1 | 0.918 | 1 | 0.244 | 0.976 | 0.597 | 1 |
FEF25–75%b | 0.853 | 1 | 0.718 | 1 | 0.197 | 0.788 | 0.819 | 1 | 0.255 | 1 | 0.847 | 1 |
First P. aeruginosa a | 0.724 | 1 | 1 | 1 | 0.473 | 1 | 0.056 | 0.224 | 1 | 1 | 0.312 | 1 |
P. aeruginosa mucoida | 0.092 | 0.368 | 0.729 | 1 | 0.289 | 1 | 1 | 1 | 0.541 | 1 | 0.107 | 0.428 |
P. aeruginosa no mucoida | 0.879 | 1 | 0.754 | 1 | 0292 | 1 | 0.776 | 1 | 1 | 1 | 0.629 | 1 |
A. xylosoxidans a | 0.619 | 1 | 0.537 | 1 | 1 | 1 | 0.35 | 1 | 0.511 | 1 | 0.52 | 1 |
S. aureus a | 0.362 | 1 | 0.175 | 0.700 | 0.391 | 1 | 1 | 1 | 1 | 1 | 0.776 | 1 |
B. cepacia a | 0.371 | 1 | 0.116 | 0.464 | 0.313 | 1 | 0.703 | 1 | 1 | 1 | 1 | 1 |