From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study
Variable | Without taking CFTRmutation into account | No CFTRmutations identified | No CFTRmutations identified with PI | One identified CFTRmutation | One identified CFTRmutation with PI | Two identified CFTRmutations | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | |
Gendera | 0.285 | 1 | 0.302 | 1 | 0.505 | 1 | 0.424 | 1 | 0.479 | 1 | 0.223 | 0.892 |
Agea | 0.437 | 1 | 0.639 | 1 | 0.382 | 1 | 0.601 | 1 | 0.777 | 1 | 0.625 | 1 |
Onset of symptomsa | 0.098 | 0.392 | 0.407 | 1 | 0.421 | 1 | 0.143 | 0.572 | 0.180 | 0.720 | 0.036 | 0.144 |
Onset of pulmonary diseasea | 0.802 | 1 | 0.091 | 0.364 | 0.163 | 0.652 | 0.424 | 1 | 0.321 | 1 | 0.980 | 1 |
Onset of digestive diseasea | 0.640 | 1 | 0.237 | 0.948 | 0.311 | 1 | 0.692 | 1 | 0.318 | 1 | 0.452 | 1 |
Diagnosisa | 0.334 | 1 | 0.620 | 1 | 0.637 | 1 | 0.715 | 1 | 0.613 | 1 | 0.218 | 0.872 |
BMIa | 0.620 | 1 | 0.376 | 1 | 0.510 | 1 | 0.848 | 1 | 0.754 | 1 | 0.665 | 1 |
Bhalla scoreb | 0.942 | 1 | 0.808 | 1 | 0.158 | 0.632 | 0.830 | 1 | 0.324 | 1 | 0.311 | 1 |
Kanga scoreb | 0.879 | 1 | 0.884 | 1 | 0.805 | 1 | 0.753 | 1 | 0.745 | 1 | 0.822 | 1 |
Shwachman-Kulczycki scoreb | 0.985 | 1 | 0.416 | 1 | 0.151 | 0.604 | 0.538 | 1 | 0.837 | 1 | 0.981 | 1 |
Nasal polyposisa | 0.582 | 1 | 0.347 | 1 | 0.285 | 1 | 0.457 | 1 | 0.631 | 1 | 0.986 | 1 |
Diabetes mellitusa | 0.255 | 1 | 0.858 | 1 | 0.917 | 1 | 0.201 | 0.804 | 0.337 | 1 | 0.383 | 1 |
Osteoporosisa | 0.562 | 1 | 0.829 | 1 | 0.108 | 0.432 | 0.339 | 1 | 0.036 | 0.144 | 0.713 | 1 |
Meconium ileus | 0.420 | 1 | 0.389 | 1 | 0.379 | 1 | 0.130 | 0.520 | 0.080 | 0.320 | 0.619 | 1 |
Pancreatic insufficiencya | 0.159 | 0.636 | 0.398 | 1 | - | - | 0.167 | 0.668 | - | - | 0.601 | 1 |
SpO2b | 0.506 | 1 | 0.201 | 0.804 | 0.128 | 0.512 | 0.422 | 1 | 0.525 | 1 | 0.278 | 1 |
FVC(%)b | 0.498 | 1 | 0.216 | 0.864 | 0.121 | 0.484 | 0.738 | 1 | 0.901 | 1 | 0.499 | 1 |
FEV1(%)b | 0.668 | 1 | 0.214 | 0.856 | 0.201 | 0.804 | 0.479 | 1 | 0.731 | 1 | 0.769 | 1 |
FEV1/FVCb | 0.615 | 1 | 0.592 | 1 | 0.671 | 1 | 0.407 | 1 | 0.686 | 1 | 0.373 | 1 |
FEF25–75%b | 0.643 | 1 | 0.326 | 1 | 0.531 | 1 | 0.548 | 1 | 0.942 | 1 | 0.851 | 1 |
First P. aeruginosa a | 0.147 | 0.588 | 0.125 | 0.500 | 0.341 | 1 | 0.146 | 0.584 | 0.027 | 0.108 | 0.264 | 1 |
P. aeruginosa mucoida | 0.559 | 1 | 0.316 | 1 | 0.366 | 1 | 0.569 | 1 | 0.285 | 1 | 0.160 | 0.640 |
P. aeruginosa no mucoida | 0.319 | 1 | 0.263 | 1 | 0.352 | 1 | 0.276 | 1 | 0.082 | 0.328 | 0.347 | 1 |
A. xylosoxidans a | 0.327 | 1 | 0.018 | 0.072 | 0.013 | 0.052 | 0.687 | 1 | 0.646 | 1 | 0.006 | 0.024 |
S. aureus a | 0.843 | 1 | 0.677 | 1 | 0.931 | 1 | 0.049 | 0.196 | 0.032 | 0.128 | 0.466 | 1 |
B. cepacia a | 0.461 | 1 | 0.734 | 1 | 0.974 | 1 | 0.150 | 0.600 | 0.243 | 0.972 | 0.671 | 1 |