Table 2 Results of the genetic association analyses for log e (CAC score + 1) using Metabochip SNPs (additive genetic model), gender and age as predictors in a linear regression model
CHR | Gene | SNP | Physical position | Minor allele (MAF) | loge(CAC score + 1) | loge(CAC +1) without CHD | dichotomized CAC | |||
|---|---|---|---|---|---|---|---|---|---|---|
Beta (95% CI) | P | Beta (95% CI) | P | OR (95% CI) | P | |||||
9 | CDKN2A/2B | rs1537373 | 22093341 | G (0.47) | 0.30 (0.21-0.39) | 4.05x10-11 | 0.26 (0.17-0.35) | 1.52x10-8 | 1.19 (1.07-1.31) | 0.001 |
rs10965219 | 22043687 | G (0.48) | 0.25 (0.16-0.39) | 1.32x10-7 | 0.23 (0.14-0.32) | 1.28x10-6 | 1.16 (1.05-1.29) | 0.005 | ||
6 | PHACTR1 | rs9349379 | 13011943 | G (0.39) | 0.30 (0.22-0.40) | 4.67x10-11 | 0.31 (0.22-0.40) | 3.48x10-11 | 1.26 (1.14-1.4) | 1.47x10-5 |