Table 1 Baseline characteristics of subjects according to cardiovascular disease status and MTTP -164 T > C genotype in EPIC-Potsdam study
CVD free by genotype | CVD by genotype | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
All CVD free | TT | CT | CC | P for trenda | All CVD | TT | CT | CC | P for trenda | |
n | 1 978 | 1 096 | 742 | 140 | 324 | 178 | 126 | 20 | ||
age, yrs | 49.8 ± 0.2 | 49.5 ± 0.3 | 49.2 ± 0.3 | 49.4 ± 0.7 | 0.543 | 54.9 ± 0.5 | 56.1 ± 0.6 | 54.1 ± 0.7 | 56.6 ± 1.7 | 0.223 |
Men, % | 36.8 | 36.7 | 35.3 | 35.0 | 0.687 | 58.5 | 64.3 | 60.9 | 69.4 | 0.654 |
Abdominal obesity, %b | 21.4 | 20.9 | 20.3 | 18.8 | 0.567 | 26.9 | 32.2 | 30.9 | 30.0 | 0.837 |
Obesity, %c | 14.9 | 14.5 | 15.5 | 9.7 | 0.134 | 18.4 | 19.9 | 19.4 | 19.6 | 0.975 |
Hypertension, % | 47.6 | 45.6 | 44.7 | 43.7 | 0.592 | 60.3 | 70.8 | 68.3 | 49.0 | 0.114 |
Current smokers, % | 21.4 | 21.2 | 22.5 | 21.4 | 0.957 | 39.7 | 35.7 | 31.6 | 47.9 | 0.264 |
High education, % | 41.7 | 44.2 | 38.7 | 44.4 | 0.978 | 34.1 | 31.8 | 30.3 | 36.1 | 0.699 |
High sport activity, % | 24.8 | 25.2 | 24.4 | 27.5 | 0.230 | 19.9 | 18.0 | 13.0 | 23.5 | 0.534 |
Cholesterol, mg/dL | 191 ± 0.9 | 189 ± 1.2 | 192 ± 1.5 | 195 ± 3.4 | 0.036 | 198 ± 2.3 | 210 ± 3.3 | 199 ± 3.9 | 199 ± 9.7 | 0.033 |
HDL-cholesterol, mg/dL | 52 ± 0.3 | 52 ± 0.4 | 52 ± 0.5 | 52 ± 1.2 | 0.840 | 50 ± 0.8 | 50 ± 1.1 | 51 ± 1.3 | 47 ± 3.2 | 0.575 |
LDL-cholesterol, mg/dL | 114 ± 0.8 | 112 ± 1.0 | 115 ± 1.2 | 116 ± 2.8 | 0.026 | 120 ± 1.9 | 128 ± 2.7 | 121 ± 3.2 | 129 ± 7.9 | 0.305 |
Triglyceride, mg/dLd | 107 (105-110) | 105 (101-108) | 108 (104-112) | 114 (104-124) | 0.087 | 118 (111-125) | 131 (120-144) | 116 (104-129) | 99 (76-129) | 0.016 |
Alcohol consumption, g/day | 8.0 (7.5-8.5) | 8.2 (7.6-8.9) | 7.5 (6.8-8.2) | 9.5 (7.6-11.7) | 0.871 | 5.9 (5.1-6.9) | 5.5 (4.3-7.0) | 5.8 (4.4-7.6) | 3.9 (2.0-7.9) | 0.663 |