Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

Chatterjee, Arpita; Dutta, Samikshan; Mukherjee, Sanjit; Mukherjee, Nupur; Dutta, Avirup; Mukherjee, Ashis; Sinha, Swagata; Panda, Chinmay Kumar; Chaudhuri, Keya; Roy, Ananda L; Mukhopadhyay, Kanchan

doi:10.1186/1471-2350-14-12

BMC Medical Genetics

Table 7 Individual and interactive effects of SIM2 and ETS2 SNPs in families with DS probands (analyzed by MDR 2.0 beta 8.1)

From: Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

SNP ID (individual effect)	Interactive effects
SNP ID (individual effect)	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Father
rs2073601(1.77)	-	−0.06	−1.00	−0.72	−1.49	−1.07	−1.22	−0.82	−1.24	−0.99	−0.99	−0.09	−0.08	−1.12	−1.79
rs2073416 (0.94)		-	−0.65	−0.05	−0.73	−1.12	0.92	−0.37	0.83	−0.46	−0.46	1.41	1.64	0.72	−0.51
rs2269188 (0.22)			-	1.10	−0.54	−0.38	0.55	1.32	0.50	0.69	0.69	−0.20	−0.07	0.38	0.12
rs461155 (0.70)				-	−0.40	0.39	−0.08	−0.11	0.55	−0.19	−0.19	−0.62	−0.54	−0.40	−0.12
rs1051425 (0.38)					-	−0.58	0.69	−0.18	−0.09	0.55	0.55	0.09	0.19	−0.19	−0.05
rs374575 (0.65)						-	−0.58	−0.38	−0.85	−0.66	−0.66	−0.87	−0.81	−0.57	−0.42
rs2070529 (0.17)							-	−0.14	−0.43	−0.18	−0.18	−0.25	−0.18	−0.67	0.06
rs2070530 (0.44)								-	−0.41	0	0	−0.15	−0.06	1.16	−0.21
rs2070531 (0.49)									-	−0.41	−0.41	3.43	3.78	2.07	0.37
rs6517481 (0.34)										-	−0.41	3.21	3.53	0.37	0.04
rs7276961 (0.34)											-	3.21	3.53	0.37	0.04
rs1051475 (2.09)												-	−2.67	−0.69	0.24
rs1051476 (2.29)													-	−0.66	0.46
rs11254 (0.09)														-	−0.11
rs711 (3.08)															-
Mother
rs2073601 (1.38)	-	−1.49	−2.99	−0.16	−1.27	−1.38	−0.75	−0.62	−0.14	−0.09	−0.09	−0.67	−0.75	−1.31	−1.40
rs2073416 (1.96)		-	−4.27	−0.25	−1.45	−1.34	−0.17	−0.17	−0.45	−0.46	−0.46	−0.84	0.03	−0.05	−1.64
rs2269188 (17.17)			-	−3.97	−3.97	−4.13	−3.25	−2.90	−3.71	−4.19	−4.19	−5.05	−4.92	−3.47	−4.23
rs461155 (1.06)				-	−0.36	0.19	0.02	0.22	0.44	0.49	0.49	−0.46	−0.53	−0.21	−0.84
rs1051425 (1.11)					-	−0.95	0.19	−0.25	−1.03	−0.84	−0.84	−0.23	−0.31	−0.84	−0.59
rs374575 (1.10)						-	−0.75	−0.41	−0.56	−0.66	−0.66	−0.97	−1.03	−0.69	−0.02
rs2070529 (0.63)							-	−0.54	0.14	0.19	0.19	−0.09	−0.16	2.27	0.66
rs2070530 (0.73)								-	0.16	0.3	0.3	0.19	0.07	2.43	0.92
rs2070531(0.36)									-	−0.47	−0.47	2.8	2.6	5.71	0.52
rs6517481 (0.30)										-	−0.51	2.07	1.9	2.97	0.73
rs7276961 (0.30)											-	2.07	1.9	2.97	0.73
rs1051475 (1.47)												-	−1.71	−0.72	−1.17
rs1051476 (1.34)													-	−0.75	−1.04
rs11254 (0.66)														-	−0.67
rs711 (4.03)															-
Probands with DS
rs2073601 (1.92)	-	−0.37	0.09	−0.34	−0.67	−0.26	−0.81	−0.57	−1.28	−1.14	−1.14	−1.83	−1.74	−3.83	−2.56
rs2073416 (0.26)		-	1.10	−0.22	−0.46	0.12	−0.17	−0.41	−0.39	−1.27	−1.27	−0.49	−0.43	−2.17	−1.72
rs2269188 (0.87)			-	1.35	−0.92	−0.03	0.56	−0.34	0.94	−0.13	−0.13	−0.39	−0.27	−2.78	−2.46
rs461155 (2.64)				-	−1.08	0.40	−0.99	−2.07	−0.58	−1.27	−1.27	−1.98	−2.08	−11.9	−3.42
rs1051425 (1.21)					-	−0.24	−0.84	−1.36	−0.80	−1.69	−1.69	−0.74	−0.62	−2.60	−0.10
rs374575 (0.03)						-	−0.23	−0.37	0	−0.76	−0.76	−0.48	−0.46	−1.94	−0.47
rs2070529 (1.47)							-	−1.61	−0.4	−0.96	−0.96	−0.99	−0.88	−8.74	−1.09
rs2070530 (3.04)								-	−0.77	−1.38	−1.38	−1.7	−1.76	−13.5	−1.98
rs2070531 (1.09)									-	−1.03	−1.03	−0.8	−0.71	−8.71	−1.31
rs6517481 (1.66)										-	−2.73	−1.79	−1.71	−5.3	−2.77
rs7276961 (1.66)											-	−1.79	−1.71	−5.3	−2.77
rs1051475 (2.24)												-	−2.68	−7.08	−2.15
rs1051476 (2.56)													-	−6.21	−2.47
rs11254 (29.78)														-	−3.58
rs711(4.26)															-

1 = rs2073601, 2 = rs2073416, 3 = rs2269188, 4 = rs461155, 5 = rs1051425, 6 = rs374575, 7 = rs2070529, 8 = rs2070530, 9 = rs2070531, 10 = rs6517481, 11 = rs7276961, 12 = rs1051475, 13 = rs1051476, 14 = rs11254, 15 = rs711 (Entropy values mentioned in bold are in synergistic interaction).

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ISSN: 1471-2350

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