Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

Chatterjee, Arpita; Dutta, Samikshan; Mukherjee, Sanjit; Mukherjee, Nupur; Dutta, Avirup; Mukherjee, Ashis; Sinha, Swagata; Panda, Chinmay Kumar; Chaudhuri, Keya; Roy, Ananda L; Mukhopadhyay, Kanchan

doi:10.1186/1471-2350-14-12

BMC Medical Genetics

Table 6 Pair wise LD pattern of studied SNPs

From: Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

D′	rs6517481	rs7276961	rs1051475	rs1051476	rs2070529	rs2070530	rs2070531	rs461155	rs11254
r²
Control
rs6517481	-	1	0.926	0.926	0.909	0.930	0.949	0.735	0.719
rs7276961	1	-	0.926	0.926	0.909	0.930	0.949	0.735	0.719
rs1051475	0.774	0.774	-	1	0.899	0.923	0.944	0.765	0.722
rs1051476	0.774	0.774	1	-	0.899	0.923	0.944	0.765	0.722
rs2070529	0.499	0.499	0.441	0.441	-	1	0.955	0.836	0.660
rs2070530	0.501	0.501	0.445	0.445	0.958	-	0.977	0.849	0.680
rs2070531	0.902	0.902	0.805	0.805	0.551	0.553	-	0.757	0.718
rs461155	0.366	0.366	0.362	0.362	0.622	0.615	0.389	-	0.612
rs11254	0.491	0.491	0.503	0.503	0.250	0.255	0.490	0.240	-
Father of DS proband
rs6517481	-	1	0.856	0.853	0.871	0.954	0.905	0.907	0.845
rs7276961	1	-	0.856	0.853	0.871	0.954	0.905	0.907	0.845
rs1051475	0.579	0.579	-	1	0.710	0.797	0.888	0.799	0.897
rs1051476	0.560	0.560	0.974	-	0.717	0.802	0.886	0.805	0.931
rs2070529	0.423	0.423	0.369	0.387	-	0.974	0.956	0.807	0.876
rs2070530	0.450	0.450	0.399	0.415	0.841	-	1	0.848	1
rs2070531	0.796	0.796	0.606	0.586	0.494	0.479	-	0.903	0.905
rs461155	0.417	0.417	0.398	0.414	0.579	0.703	0.400	-	0.861
rs11254	0.714	0.714	0.643	0.674	0.442	0.494	0.795	0.376	-
Mother of DS proband
rs6517481	-	1	0.828	0.830	0.919	0.918	0.979	0.769	0.916
rs7276961	1	-	0.828	0.830	0.919	0.918	0.979	0.769	0.916
rs1051475	0.549	0.549	-	1	0.658	0.671	0.849	0.548	0.926
rs1051476	0.563	0.563	0.981	-	0.679	0.693	0.849	0.571	0.927
rs2070529	0.538	0.568	0.346	0.362	-	1	1	0.745	0.918
rs2070530	0.528	0.528	0.346	0.363	0.982	-	1	0.750	0.916
rs2070531	0.920	0.920	0.552	0.565	0.612	0.601	-	0.759	0.937
rs461155	0.370	0.370	0.228	0.243	0.535	0.563	0.346	-	0.728
rs11254	0.823	0.823	0.663	0.677	0.527	0.515	0.861	0.316	-
DS proband
rs6517481	-	1	0.865	0.862	0.875	0.975	0.939	0.761	0.255
rs7276961	1	-	0.865	0.862	0.875	0.975	0.939	0.761	0.255
rs1051475	0.710	0.710	-	1	0.830	0.926	0.903	0.774	0.274
rs1051476	0.680	0.680	0.966	-	0.807	0.903	0.885	0.756	0.266
rs2070529	0.501	0.501	0.476	0.458	-	0.949	0.825	0.812	0.256
rs2070530	0.593	0.593	0.565	0.546	0.859	-	0.911	0.823	0.273
rs2070531	0.754	0.754	0.735	0.718	0.523	0.608	-	0.699	0.269
rs461155	0.375	0.375	0.410	0.404	0.659	0.645	0.376	-	0.167
rs11254	0.039	0.039	0.043	0.039	0.026	0.028	0.037	0.011	-
ALL
rs6517481	-	1	1	1	1	1	1	0.761	1
rs7276961	1	-	1	1	1	1	1	0.761	1
rs1051475	0.939	0.939	-	1	0.926	1	1	0.698	1
rs1051476	0.939	0.939	1	-	0.926	1	1	0.698	1
rs2070529	0.698	0.698	0.638	0.638	-	1	0.926	0.748	0.858
rs2070530	0.625	0.625	0.665	0.665	0.894	-	1	0.731	1
rs2070531	0.939	0.939	1	1	0.638	0.665	-	0.698	1
rs461155	0.428	0.428	0.383	0.383	0.529	0.451	0.383	-	0.636
rs11254	0.883	0.883	0.940	0.940	0.582	0.708	0.940	0.339	-
BC
rs6517481	-	1	0.884	0.884	1	1	1	0.5	0.122
rs7276961	1	-	0.884	0.884	1	1	1	0.5	0.122
rs1051475	0.741	0.741	-	1	1	1	0.884	0.891	0.077
rs1051476	0.741	0.741	1	-	1	1	0.884	0.891	0.077
rs2070529	0.631	0.631	0.605	0.605	-	1	1	0.495	0.274
rs2070530	0.605	0.60	0.582	0.582	1	-	1	0.495	0.269
rs2070531	1	1	0.741	0.741	0.631	0.605	-	0.5	0.122
rs461155	0.125	0.125	0.350	0.350	0.204	0.204	0.125	-	0.425
rs11254	0.013	0.013	0.001	0.001	0.041	0.038	0.013	0.088	-
OC
rs6517481	-	1	0.948	0.948	1	1	1	0.334	0.899
rs7276961	1	-	0.948	0.948	1	1	1	0.334	0.899
rs1051475	0.697	0.697	-	1	1	1	0.950	0.632	0.907
rs1051476	0.697	0.697	1	-	1	1	0.950	0.632	0.907
rs2070529	0.607	0.607	0.471	0.471	-	1	1	0.391	0.856
rs2070530	0.630	0.630	0.488	0.488	0.963	-	1	0.306	0.861
rs2070531	0.960	0.960	0.728	0.728	0.582	0.605	-	0.306	0.902
rs461155	0.060	0.060	0.168	0.168	0.137	0.049	0.049	-	0.656
rs11254	0.656	0.656	0.787	0.787	0.360	0.378	0.687	0.189	-

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com