Table 3 Anthropometric and quantitative metabolic characteristics of 5,645 middle-aged Danish Inter99 participants stratified according to the AGPAT6 rs890220 genotype

N (men/women)

3995(1976/2019)

1368(654/714)

134(67/67)

Age (years)

45.8 ± 7.9

46.3 ± 7.7

45.9 ± 8.0

Waist (cm)

85.9 ± 13.0

86.1 ± 12.8

83.3 ± 12.1

0.48

BMI (kg/m²)

26.0 ± 4.5

26.1 ± 4.2

25.4 ± 4.0

0.60

Serum Triglycerides (mmol/l)

1.3 ± 1.5

1.3 ± 0.9

1.3 ± 1.2

0.50

Serum Total cholesterol (mmol/l)

5.5/-1.1

5.6 ± 1.0

5.5 ± 1.1

0.084

Serum HDL cholesterol (mmol/l)

1.4 ± 0.4

1.5 ± 0.4

1.4 ± 0.4

0.86

Plasma glucose (mmol/l)

  Fasting

5.45 ± 0.52

5.47 ± 0.50

5.42 ± 0.50

0.74

  120 min

5.95 ± 1.56

5.96 ± 1.51

5.76 ± 1.50

0.44

Serum insulin (pmol/l)

  Fasting

41 ± 27

40 ± 25

39 ± 23

0.74

  120 min

209 ± 199

201 ± 189

193 ± 146

0.63

Insulin secretion indices

Insulinogenic index

29.7 ± 19.3

30.0 ± 20.1

33.0 ± 23.1

0.22

BIGTT-AIR

1861 ± 1088

1852 ± 1067

1930 ± 1210

0.63

Insulin sensitivity indices

HOMA-IR (pmol x mmol/l)

10.03 ± 6.85

9.96 ± 6.796

9.58 ± 6.21

0.81

BIGTT-S_I

9.44 ± 4.00

9.42 ± 3.79

9.54 ± 3.73

0.26

Stumvoll S_I

0.10 ± 0.02

0.10 ± 0.02

0.10 ± 0.02

0.085

Matsuda S_I

9.17 ± 5.78

9.04 ± 5.34

9.20 ± 6.47

0.85