Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene

BMC Medical Genetics

Table 1 Clinical and biological data of the tumors

Sample	INSS	INRG	Gender	1p-del	MNA	11q-del	17q-gain	Genomic profile*	5-year OS	Sanger	NGS
3E2	4	M	Ma	neg	neg	pos	pos	11q-del	DOD		+
4E1	4	M	F	neg	neg	pos	pos	11q-del	DOD		+
5E1	2A	L	F	neg	neg	neg	neg	Num only	NED	+
6E9	3	L	Ma	pos	neg	pos	pos	11q-del	DOD		+
8E4	1	L	F	neg	neg	neg	neg	Num only	NED	+
8E5	3	L	F	neg	neg	neg	neg	Num only	NED	+
11E1	4	M	F	neg	neg	pos	pos	11q-del	NED		+
11E4	4	M	F	neg	neg	pos	pos	11q-del	DOD		+
11E8	1	L	Ma	neg	neg	neg	neg	Num only	NED	+	+
12E5	4S	MS	Ma	neg	neg	neg	neg	Num only	NED	+
13E7	4S	MS	F	neg	neg	neg	neg	Num only	NED	+
15E7	3	L	Ma	neg	neg	neg	neg	Num only	DSC	+
16E1	1	L	F	neg	neg	neg	neg	Num only	NED	+
16E2	4S	L	Ma	neg	neg	neg	neg	Num only	NED	+
17E5	4	M	F	neg	neg	neg	neg	Num only	DOD	+
18E2	1	L	F	neg	neg	pos	pos	11q-del	NED		+
18E5	1	L	F	neg	neg	neg	neg	Num only	NED	+
9R9	3	M	F	pos	neg	pos	pos	11q-del	DOD		+
10R6	2A	L	Ma	neg	neg	neg	neg	Num only	NED	+
10R8	3	L	F	neg	neg	pos	neg	Num only	DOD		+
13R1	3	L	Ma	pos	pos	neg	pos	MNA	DOD		+
15R8	3	M	Ma	pos	neg	pos	pos	11q-del	NED		+
23R4	2	L	F	neg	neg	neg	neg	Num only	NED	+
25R6	4	M	Ma	pos	pos	neg	pos	MNA	DOD		+
25R7	1	L	Ma	pos	neg	neg	neg	Other segm.	NED	+
26R1	1	L	Ma	neg	neg	neg	neg	Num only	NED	+
27R1	2A	L	F	neg	neg	neg	neg	Num only	NED	+
27R7	2	L	Ma	neg	neg	neg	neg	Num only	NED	+
28R8	4	M	Ma	neg	neg	pos	pos	11q-del	DOD		+
30R0	4	M	F	neg	neg	pos	neg	11q-del	NED		+
34R5	3	L	Ma	neg	neg	neg	neg	Num only	NED	+
37R5	1	L	Ma	neg	neg	neg	neg	Num only	NED	+
44R5	1	L	F	neg	neg	neg	neg	Num only	NED		+
46R6	4	M	Ma	neg	neg	pos	pos	11q-del	NED		+
47R4	4	M	F	neg	neg	pos	pos	11q-del	NED		+
49R1	4	M	Ma	neg	neg	pos	pos	11q-del	NED		+
52R2	1	L	Ma	neg	neg	neg	pos	17q-gain	NED		+

Abbreviations: INSS International Neuroblastoma Staging System [7], INRG International Neuroblastoma Risk Group [8], M metastatic, L localized, Ma male, F female, neg negative, pos positive, MNA NMYC-amplification, NED no evidence of disease, DOD dead of disease, DSC dead of surgical complications. *As defined by Carén et al [6].

ISSN: 1471-2350