Family-based associations in measures of psychological distress and quality of life in a cardiac screening clinic for inheritable cardiac diseases: a cross-sectional study

Table 7 Multiple regression models examining associations with a clinically significant HADS score

	Model 1: Multiple logistic regression			Model 2: Multi level multiple logistic regression
	Odds ratio	95% CI	P value	Odds ratio	95% CI	P value
Male sex	0.54	0.29, 1.01	0.054	0.52	0.26, 1.03	0.062
Married (vs single/ divorced)	0.42	0.19, 0.92	0.031	0.40	0.17, 0.96	0.040
Third level education or higher	0.31	0.14, 0.71	0.006	0.31	0.13, 0.74	0.009
First degree relative to proband	2.91	1.26, 6.73	0.013	3.18	1.22, 8.31	0.018

Footnote. Multivariable models adjusted for age. Model 1 is a multivariable logistic regression, with a clinically significant HADS score as the outcome variable and adjusted for age. Model 2 is a multivariable logistic regression model with a random effects variable for family and adjusted for age. Log likelihood for model 1 is −130.45, and −130.05 for model 2. For the random effects model 2, the random intercept (ψ) is 0.253, and the estimated intraclass correlation of the latent responses (ρ) is 0.071.

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