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Table 2 Mean difference in fasting glucose and HbA1c levels per weighted allele of genetic risk score in children

From: Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children

Genetic risk score

N

Fasting glucose (mmol/l)

p-value

N

Adjusted by PCs

p-value

FGGRS

573

0.02 (0.01, 0.03)

7.1x10-5

522

0.02 (0.01, 0.03)

0.001

T2DGRS

511

0.003 (−0.01, 0.01)

0.59

467

0.003 (−0.01, 0.01)

0.61

 

N

HbA1c (%)

p-value

N

Adjusted by PCs

p-value

FGGRS

1037

0.02 (0.01, 0.02)

1.6x10-6

933

0.02 (0.01, 0.02)

1.4x10-5

T2DGRS

918

0.004 (−0.002, 0.01)

0.20

831

0.005 (−0.002, 0.01)

0.19

  1. FGGRS = fasting glucose genetic risk score.
  2. T2DGRS = type 2 diabetes genetic risk score.
  3. PCs = population stratification principal components.