Table 2 Baseline characteristics according to PNPLA3 I148M sequence variant in HCV genotype 2 patients

	II	IM	MM	P value	P value
	n = 56	n = 43	n = 4	additive	recessive
Male gender, n (%)	33 (59)	27 (63)	2 (50)	0.830	0.999
Age, years	50 (42–56)	48 (37–54)	51 (36–53)	0.370	0.887
BMI, kg/m ²	25 (23–27)	25^a (22–27)	23 (21–33)	0.773	0.981
ALT, U/l	73^a (44–150)	72 (39–137)	147 (88–455)	0.406	0.045
Total cholesterol, mmol/L	4.8^b (4.1-5.5)	4.6^a (4.2-5.1)	4.2 (3.9-5.8)	0.283	0.756
Triglycerides, mmol/L	1.0^b (0.8-1.3)	0.9^a (0.7-1.3)	0.7 (0.4-1.3)	0.094	0.065
Glucose, mmol/L	4.9^d (4.6-5.1)	5.0^e (4.5-5.4)	4.5 (4.2-5.6)	0.502	0.724
Insulin, mIU/L	10^d (5–23)	13^c (7–29)	48 (24–86)	0.027	0.001
HOMA-IR, U	1.9^e (1.1-4.5)	2.9^f (1.4-6.7)	9.0 (4.8-21.7)	0.023	0.005
Baseline HCV RNA, log ₁₀ IU/mL	6.5 (6.0-6.9)	6.4 (5.3-6.8)	5.3 (4.7-6.4)	0.005	0.073
Steatosis ¹ , n (%)	23^b (43)	23^a (55)	3 (75)	0.327	0.362
Cirrhosis ² , n (%)	7^b (13)	6^a (14)	1 (25)	0.669	0.462
Diabetes mellitus, n (%)	3^d (6)	1^e (3)	0 (0)	0.694	0.998

Categorical traits, expressed as number (n) and relative proportion (%), have been compared by Fisher exact test. Continuous traits are expressed as median (interquartile range) and have been analyzed using a linear regression model. For additional information on statistical analyses, see methods.
¹Steatosis was defined as histological grade > 0. ²Cirrhosis was defined as Ishak stage 5–6.
Missing data: ^an = 1, ^bn = 3, ^cn = 5, ^dn = 2, ^en = 4, ^fn = 9.
Abbreviations: PNPLA3, patatin-like phospholipase domain-containing 3; HCV, hepatitis C virus; BMI, body mass index; ALT, alanine transferase; HOMA-IR, homeostasis model assessment for insulin resistance; II, individuals with two 148I alleles; MM, individuals with two 148 M alleles; IM, heterozygotes.

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