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PNPLA 3I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection

  • Karolina Rembeck1,
  • Cristina Maglio2,
  • Martin Lagging1,
  • Peer Brehm Christensen3,
  • Martti Färkkilä4,
  • Nina Langeland5,
  • Mads Rauning Buhl6,
  • Court Pedersen3,
  • Kristine Mørch5,
  • Gunnar Norkrans1,
  • Kristoffer Hellstrand1,
  • Magnus Lindh1,
  • Carlo Pirazzi2,
  • Maria Antonella Burza2,
  • Stefano Romeo2Email author,
  • Johan Westin1Email author and
  • for the NORDynamIC group
Contributed equally
BMC Medical Genetics201213:82

DOI: 10.1186/1471-2350-13-82

Received: 27 March 2012

Accepted: 20 June 2012

Published: 14 September 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
27 Mar 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
30 May 2012 Reviewed Reviewer Report - Nicola Santoro
12 Jun 2012 Reviewed Reviewer Report - Silvia Fargion
16 Jun 2012 Reviewed Reviewer Report - Helena Cortez-Pinto
Resubmission - Version 3
Submitted Manuscript version 3
20 Jun 2012 Editorially accepted
14 Sep 2012 Article published 10.1186/1471-2350-13-82

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Infectious Diseases/Virology, Institute of Biomedicine, University of Gothenburg
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, the Sahlgrenska Academy, University of Gothenburg
Department of Infectious Diseases, University of Southern Denmark
Department of Gastroenterology, Helsinki University
Department of Medicine, Haukeland University Hospital and Institute of Medicine, University of Bergen
Department of Infectious Diseases, Aarhus University