Table 3 Association of two polymorphisms in UQCRB (complex III) with survival
SNP | Genotype | Cause of death: CRC | Cause of death: any | |||||
|---|---|---|---|---|---|---|---|---|
No. | Deaths (%) | HR (95% CI) | P value | Deaths (%) | HR (95% CI) | P value | ||
rs7836698 All patients | CC | 203 | 54 (26.6) | 1.00 | 69 (34.0) | 1.00 | ||
CT | 297 | 77 (25.9) | 0.90 (0.63–1.28) | 0.55 | 95 (32.0) | 0.87 (0.64–1.20) | 0.41 | |
TT | 106 | 18 (17.0) | 0.53 (0.31–0.91) | 0.02 | 23 (21.7) | 0.52 (0.32–0.85) | 0.01 | |
rs7836698 Colon | CC | 97 | 30 (30.9) | 1.00 | 37 (38.1) | 1.00 | ||
CT | 159 | 38 (23.9) | 0.74 (0.45–1.21) | 0.23 | 47 (29.6) | 0.75 (0.48–1.18) | 0.21 | |
TT | 69 | 10 (14.5) | 0.42 (0.21–0.87) | 0.02 | 13 (18.8) | 0.42 (0.22–0.82) | 0.01 | |
rs7836698 Rectum | CC | 105 | 23 (21.9) | 1.00 | 31 (29.5) | 1.00 | ||
CT | 137 | 39 (28.5) | 1.13 (0.67–1.90) | 0.65 | 48 (35.0) | 1.03 (0.65–1.63) | 0.89 | |
TT | 37 | 8 (21.6) | 0.73 (0.32–1.71) | 0.47 | 10 (27.0) | 0.70 (0.33–1.47) | 0.34 | |
rs10504961 All patients | CC | 134 | 34 (25.4) | 1.00 | 47 (35.1) | 1.00 | ||
CT | 319 | 78 (24.4) | 0.88 (0.58–1.33) | 0.54 | 97 (30.4) | 0.79 (0.55–1.13) | 0.19 | |
TT | 150 | 36 (24.0) | 0.76 (0.47–1.24) | 0.28 | 42 (28.0) | 0.64 (0.42–0.99) | 0.05 | |
rs10504961 Colon | CC | 64 | 22 (34.4) | 1.00 | 27 (42.2) | 1.00 | ||
CT | 168 | 38 (22.6) | 0.61 (0.35–1.05) | 0.07 | 48 (28.6) | 0.62 (0.38–1.01) | 0.06 | |
TT | 92 | 18 (19.6) | 0.47 (0.25–0.90) | 0.02 | 22 (23.9) | 0.46 (0.25–0.83) | 0.01 | |
rs10504961 Rectum | CC | 70 | 12 (17.1) | 1.00 | 20 (28.6) | 1.00 | ||
CT | 149 | 39 (26.2) | 1.33 (0.69–2.54) | 0.39 | 48 (32.2) | 0.98 (0.58–1.66) | 0.95 | |
TT | 58 | 18 (31.0) | 1.41 (0.66–2.97) | 0.37 | 20 (34.5) | 0.96 (0.51–1.81) | 0.89 | |