Figure 1From: Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity A) The pedigree of patient M11, and a chromatogram showing the missense mutation c.3446 T > A (L1149Q), B) The pedigree of patient M13, and a chromatogram showing the missense mutation c.3553 G > A (G1185R). Affected individuals carrying the mutation are marked in black and the mutations are pointed out by means of arrows.Back to article page