Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance

Table 2 Associations of APPL2 SNPs with overweight and obesity

SNP	Mayor/minor allele	Risk allele	Overweight + Obesity		Normal Weight		OR(95%CI)	p value	Empirical p value	OR(95%CI) #	p value #	Empirical p value #
			Risk allele frequencies	Genotype count 11/12/22^a	Risk allele frequencies	Genotype count 11/12/22^a
rs1107756	T/C	T	0.652	313/326/91	0.616	391/473/154	1.166(1.014-1.341)	0.031	0.128	1.160 (1.009-1.333)	0.037	0.143
rs1196768	G/A	A	0.413	253/354/126	0.387	377/480/149	1.118(0.974-1.282)	0.112	0.375	1.118 (0.974-1.283)	0.113	0.376
rs3751191	C/T	T	0.135	551/169/15	0.126	767/228/13	1.086(0.890-1.325)	0.416	0.868	1.088 (0.891-1.329)	0.409	0.868
rs2272495	C/T	C	0.746	408/290/43	0.707	507/416/88	1.218(1.047-1.416)	0.011	0.043	1.216 (1.044-1.415)	0.012	0.052
rs10861360	C/T	T	0.245	415/266/45	0.227	604/339/58	1.104(0.942-1.294)	0.220	0.611	1.099 (0.939-1.285)	0.241	0.651

^a11, major allele homozygotes; 12, heterozygotes; 22, minor allele homozygotes.
# adjust for age and sex.
Significant values are indicated in boldface.

ISSN: 1471-2350