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Table 3 Significance and odds ratios of SNPs genotyped in the replication phase

From: Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype

Gene

SNP

Minor allele and strand

Logistic regression adjusted p value

Genotypic association OR (95% CI) Heterozygous (Het) Homozygous minor (HM)

Genotype Frequencies minor/het/major Cases (Ca) Pop. Controls (PC)

LOXL1

rs2304719

T/-

0.2

Het: 1.19 (0.90 - 1.57)

Ca: 36/172/184

    

HM: 1.51 (0.91 - 2.52)

PC: 33/202/255

LOXL1

rs4461027

C/-

0.19

Het: 1.01 (0.76 - 1.36)

Ca: 55/190/148

    

HM: 0.72 (0.48 - 1.07)

PC: 91/224/177

LOXL1

rs4886782

A/-

0.033

Het: 0.84 (0.63 - 1.11)

Ca: 38/169/186

    

HM: 0.56 (0.36 - 0.87)

PC: 74/219/202

LOXL2

rs1002791

C/+

0.61

Het: 1.05 (0.79 - 1.38)

Ca: 31/155/207

    

HM: 1.31 (0.77 - 2.22)

PC: 31/192/268

LOXL2

rs17760913

T/-

0.94

Het: 1.04 (0.78 - 1.38)

Ca: 25/148/217

    

HM: 1.09 (0.62 - 1.91)

PC: 35/189/266

LOXL2

rs17760943

A/-

0.86

Het: 0.96 (0.72 - 1.27)

Ca: 25/139/229

    

HM: 0.87 (0.50 - 1.49)

PC: 29/171/293

LOXL2

rs2294125

G/+

0.43

Het: 1.01 (0.74 - 1.37)

Ca: 87/196/109

    

HM: 1.25 (0.85 - 1.83)

PC: 93/258/144

LOXL2

rs3808522

G/-

0.54

Het: 0.85 (0.63 - 1.16)

Ca: 88/176/129

    

HM: 0.97 (0.67 - 1.41)

PC: 105/240/151

LOXL2

rs3808536

C/+

0.92

Het: 1.01 (0.74 - 1.37)

Ca: 82/188/123

    

HM: 1.08 (0.74 - 1.57)

PC: 98/239/157

LOXL2

rs6985160

T/-

0.16

Het: 0.77 (0.58 - 1.02)

Ca: 50/165/178

    

HM: 1.00 (0.65 - 1.55)

PC: 56/239/200

LOXL2

rs6999447

T/-

0.31

Het: 1.25 (0.93 - 1.66)

Ca: 54/184/155

    

HM: 1.06 (0.71 - 1.60)

PC: 71/206/217

LOXL4

rs11189510

A/+

0.46

Het: 1.21 (0.88 - 1.65)

Ca: 6/100/287

    

HM: 1.34 (0.43 - 4.20)

PC: 6/109/381

LOXL4

rs11189513

G/-

0.65

Het: 0.91 (0.69 - 1.21)

Ca: 37/162/194

    

HM: 0.82 (0.52 - 1.31)

PC: 53/210/229

LOXL4

rs11599085

C/+

0.08

Het: 0.74 (0.55 - 0.99)

Ca: 54/160/178

    

HM: 0.72 (0.48 - 1.08)

PC: 79/227/186

  1. Adjusted p-value includes gender as a covariate. Because there were 14 SNPs assessed in this step, a Bonferroni correction would lead to significance with p < 0.004. The p-value displayed indicates the significance of the overall model and is adjusted for gender. The odds ratios use the homozygous major allele genotype as the reference genotype and genotype counts are presented for each group.
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BMC Medical Genetics

ISSN: 1471-2350

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