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Table 3 Variation in sex-steroid hormone synthesizing enzymes and receptor in relation to colorectal cancer risk in the Women's Health Initiative Observational Cohort

From: Estrogen and progesterone-related gene variants and colorectal cancer risk in women

Gene/Variant

N total (case/control)

MAF %1(case/control)

OR (95% CI) 2

P trend 3

corrected P trend 4

CYP17A1

     

rs10883782

410/834

15/18

0.78 (0.61-0.98)

0.03

0.22

rs17724534

406/829

15/12

1.39 (1.08-1.78)

0.009

0.07

CYP19A1

     

rs1902584

410/811

6/5

1.45 (1.07-1.98)

0.02

0.36

ESR1

     

rs9340837

424/866

12/9

1.37 (1.05-1.79)

0.02

0.73

CYP17A1

     

rs10883782

47/102

17/13

1.40 (0.72-2.73)

0.32

0.92

rs17724534

50/103

1/4

0.22 (0.03-1.74)

0.12

0.72

CYP19A1

     

rs1902584

52/108

6/7

0.79 (0.28-2.25)

0.67

0.99

ESR1

     

rs9340837

52/107

46/46

1.02 (0.64-1.62)

0.95

0.99

  1. 1. MAF = minor allele frequency.
  2. 2.For each variant, odds ratios are per copy of the risk allele.
  3. 3. Pointwise 10,000 permutation tests.
  4. 4. Familywise 10,000 permutation tests.
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BMC Medical Genetics

ISSN: 1471-2350

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