Table 2 Significant results obtained from stepwise linear regression analysis of serum PON activity (square root transformed) with SLE disease status, age, BMI, smoking, PON1/rs662 (p.Gln192Arg), PON1/rs854560 (p.Leu55Met) and PON3/rs17884563 SNPs and 13 PON2 tagSNPs
FACTOR | MAF | Beta | P | R 2 |
|---|---|---|---|---|
disease |  | -2.22 | 3.8 × 10-8 | 0.015 |
age | Â | 0.04 | 0.013 | 0.003 |
PON1/rs662 (p.Gln192Arg) | 0.280 | 10.54 | <2.0 × 10-16 | 0.392 |
PON1/rs854560 (p.Leu55Met) | 0.358 | -1.96 | 1.1 × 10-8 | 0.017 |
PON3/rs17884563 | 0.092 | -1.03 | 0.082 | 0.001 |
PON2/rs13306702 | 0.017 | 3.87 | 0.005 | 0.004 |
PON2/rs6954345 (p.Ser311Cys) | 0.233 | 2.22 | 2.1 × 10-6 | 0.011 |
PON2/rs987539 | 0.454 | -3.64 | 3.4 × 10-5 | 0.009 |
PON2/rs11982486 | 0.330 | -2.84 | 7.0 × 10-4 | 0.006 |
PON2/rs4729189 | 0.223 | -2.61 | 0.003 | 0.004 |