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Table 4 Quantitative traits stratified according to GCKR genotypes in non-diabetic controls

From: Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study

 

n

BMI (kg/m2)

Waist circumference (cm)

Fasting glucose (mmol/l)

Total cholesterol* (mmol/l)

Triglyceride* (mmol/l)

HDL-C* (mmol/l)

LDL-C* (mmol/l)

Systolic BP (mmHg)

Diastolic BP (mmHg)

rs8179206

          

AA

1076

23.50 ± 0.09

80.50 ± 0.29

4.86 ± 0.01

5.11 ± 0.03

1.45 ± 0.02

1.32 ± 0.01

3.01 ± 0.03

119.14 ± 0.46

77.95 ± 0.27

AG

68

23.33 ± 0.39

81.48 ± 1.23

4.86 ± 0.05

5.04 ± 0.11

1.52 ± 0.09

1.30 ± 0.03

2.95 ± 0.10

122.28 ± 1.99

79.55 ± 1.11

GG$

2

19.47 ± /

68.00 ± /

4.10 ± /

3.80 ± /

0.90 ± /

1.16 ± /

2.23 ± /

110.00 ± /

70.00 ± /

P valuea#

 

0.36

0.33

0.19

0.27

0.51

0.61

0.53

0.45

0.76

P valueb#

   

0.15

0.31

0.49

0.24

0.64

0.35

0.72

rs2293572

          

GG

842

23.53 ± 0.10

80.60 ± 0.32

4.85 ± 0.01

5.09 ± 0.03

1.44 ± 0.02

1.32 ± 0.01

3.00 ± 0.03

119.32 ± 0.53

78.13 ± 0.31

GC

276

23.37 ± 0.17

80.22 ± 0.58

4.87 ± 0.02

5.16 ± 0.06

1.51 ± 0.04

1.31 ± 0.02

3.03 ± 0.05

118.96 ± 0.90

77.54 ± 0.50

CC

23

24.03 ± 0.53

80.00 ± 1.85

4.98 ± 0.06

5.39 ± 0.19

1.53 ± 0.15

1.39 ± 0.06

3.12 ± 0.17

121.24 ± 1.95

78.96 ± 1.29

P valuea#

 

0.48

0.63

0.18

0.17

0.28

0.54

0.74

0.14

0.24

P valueb#

   

0.14

0.17

0.15

0.37

0.73

0.19

0.44

rs3817588

          

AA

598

23.35 ± 0.12

79.88 ± 0.40

4.85 ± 0.02

5.13 ± 0.04

1.50 ± 0.03

1.32 ± 0.01

3.02 ± 0.04

119.27 ± 0.66

77.79 ± 0.38

AG

423

23.52 ± 0.15

81.14 ± 0.47

4.87 ± 0.02

5.08 ± 0.05

1.41 ± 0.03

1.33 ± 0.02

3.00 ± 0.04

118.93 ± 0.76

78.12 ± 0.45

GG

103

23.97 ± 0.30

82.13 ± 1.01

4.84 ± 0.04

4.99 ± 0.10

1.26 ± 0.05

1.32 ± 0.03

2.95 ± 0.08

119.58 ± 1.68

77.77 ± 0.94

P valuea#

 

0.15

0.04

0.84

0.35

0.001&

0.78

0.82

0.59

0.76

P valueb#

   

0.81

0.29

0.00004&

0.70

0.84

0.39

0.63

rs780094

          

AA

368

23.22 ± 0.16

79.66 ± 0.50

4.84 ± 0.02

5.12 ± 0.05

1.49 ± 0.04

1.32 ± 0.02

3.02 ± 0.05

119.13 ± 0.87

77.83 ± 0.50

AG

558

23.59 ± 0.13

80.80 ± 0.42

4.86 ± 0.02

5.13 ± 0.04

1.44 ± 0.03

1.32 ± 0.01

3.02 ± 0.04

119.73 ± 0.70

78.40 ± 0.39

GG

218

23.67 ± 0.20

81.34 ± 0.70

4.85 ± 0.03

5.00 ± 0.07

1.35 ± 0.04

1.32 ± 0.02

2.92 ± 0.06

119.15 ± 1.04

77.33 ± 0.62

P valuea#

 

0.15

0.16

0.74

0.32

0.06

0.79

0.40

0.96

0.24

P valueb#

   

0.63

0.31

0.03

0.30

0.43

0.99

0.18

  1. Data are expressed as the means ± SEM
  2. a Adjusted for year of birth and sex
  3. b Adjusted for year of birth, sex and BMI
  4. * Variables were log-transformed before statistical analysis; numbers in the table were back-transformed
  5. # p for trend
  6. $ This group had too few subjects and no SEM was calculated
  7. &Significant after Bonferroni correction (p < 0.0014 (0.05/36) was the corrected statistically significant level in association analysis between the individual SNP and quantitative traits in the control group)
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BMC Medical Genetics

ISSN: 1471-2350

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