Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study

Table 3 Allelic distribution of GCKR polymorphisms and association with type 2 diabetes

Alleles	Non-DM (%)	DM (%)	Odds Ratio1^a	95% CI	P value	Odds Ratio2^b	95% CI	P value
rs8179206
A	97.0	96.6	1	(Ref.)		1	(Ref.)
G	3.0	3.4	1.18	0.85-1.65	0.32	1.29	0.91-1.82	0.15
rs2293572
G	85.9	85.6	1	(Ref.)		1	(Ref.)
C	14.1	14.4	1.04	0.88-1.23	0.64	1.04	0.88-1.24	0.64
rs3817588
A	72.1	68.0	1	(Ref.)		1	(Ref.)
G	27.9	32.0	1.21	1.06-1.39	0.004*	1.24	1.08-1.43	0.002*
rs780094
A	56.6	52.6	1	(Ref.)		1	(Ref.)
G	43.4	47.4	1.19	1.05-1.34	0.005*	1.22	1.07-1.38	0.002*

^a Adjusted for year of birth and sex
^b Adjusted for year of birth, sex and BMI
*Significant after Bonferroni correction (p < 0.0125 (0.05/4) was the corrected statistically significant level in association analysis between the individual SNP and type 2 diabetes)
The major allele was used as a reference when comparing the risk of diabetes between alleles.

ISSN: 1471-2350