| Events/Total | Risk allele frequency | Hazard ratios | ||||
---|---|---|---|---|---|---|---|
 | Arg/Arg | Arg/Trp | Trp/Trp |  | Arg/Arg | Arg/Trp | Arg carriers |
CARE[6]1 | 16/155 | 82/636 | 44/542 | 35.5 | 1.33 (P = 0.33) | 1.54 (P = 0.02) | 1.50 (P = 0.03) |
WOSCOPS[6]2 | 35/94 | 137/341 | 104/360 | 33.3 | 1.48 (P = 0.11) | 1.56 (P = 0.006) | 1.55 (P = 0.005) |
ARIC [13]3 | 144/1252 | 474/4363 | 382/3926 | 36.0 | 1.22 (P = 0.03) | 1.12 (P = 0.09) | (P = 0.02)8 |
Woman's Health Study [11]4 | 95/3249 | 349/11831 | 256/10203 | 36.3 | 1.25 (P = 0.09) | 1.23 (P = 0.02) | 1.24 (P = 0.01) |
PROSPER with vascular disease [8]5 | 25/159 | 119/573 | 83/514 | 35.8 | 1.02 (P = 0.95) | 1.36 (P = 0.03) | 1.28 (P = 0.07) |
PROSPER without vascular disease [8]5 | 13/209 | 70/759 | 69/668 | 36.0 | 0.64 (P = 0.15) | 0.87 (P = 0.43) | 0.82 (P = 0.23) |
Heart Protection Study [9]6 | Â | Â | Â | Â | Â | Â | 1.17 (P = 0.2) |
CHS-White [12]7 | Â | Â | Â | Â | Â | Â | 1.29 (P = 0.005) |
CHS-Black [12]7 | Â | Â | Â | Â | Â | Â | 4.14 (P = 0.08) |