The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers

Table 1 Baseline characteristics of the study populations

	UK Smoking Cohort	Smoking Controls	COPD Cases	GOLD stage 3 and 4	Comparison (smoking controls vs. COPD cases	Comparison (smoking controls vs. GOLD 3/4
Age	63.33 ± 10.29	54.38 ± 9.52	65.96 ± 9.01	67.16 ± 8.56	p < 0.0001	p < 0.0001
Female (%)	43.8	56.3	39.9	38.8	p = 0.037	p = ns
Baseline FEV₁ % predicted	56.05 ± 28.16	96.03 ± 12.15	40.31 ± 15.63	31.46 ± 8.69	p < 0.0001	p < 0.0001
FEV₁/FVC Ratio	55.34 ± 17.43	77.30 ± 5.90	46.3 ± 12.5	41.57 ± 11.20	p < 0.0001	p < 0.0001
Post BD FEV₁ % predicted	59.08 ± 27.14	99.48 ± 11.72	44.65 ± 15.52	35.28 ± 8.90	p = 0.049	p < 0.0001
PostBD FEV₁/FVC Ratio	55.58 ± 17.71	79.10 ± 5.05	46.2 ± 12.00	41.27 ± 10.46	p < 0.0001	p < 0.0001
Pack Years	43.54 ± 26.05	32.74 ± 20.04	47.61 ± 27.01	47.96 ± 27.85	p < 0.0001	p < 0.0001
GOLD Stage (%):
• Stage 1	6.9	0.0	0.0	0.0
• Stage 2	32.6	0.0	34.8	0.0
• Stage 3	42.4	0.0	45.5	69.9
• Stage 4	18.2	0.0	19.7	30.1
Number	992	176	599	389

FEV₁, Forced expiratory volume in one second; FVC, forced vital capacity; BD, bronchodilator. Control subjects were defined as having postBD (salbutamol) FEV₁ > 80% and postBD FEV₁/FVC > 0.7. Subjects with COPD were defined as having postBD FEV₁ < 80% and FEV₁/FVC < 0.7. Individuals who did not meet these criteria were excluded from analyses. Continual variables between groups were compared by Independent T-Test, categorical variables by Pearson chi square.

ISSN: 1471-2350