Genome-wide association study identifies PERLD1 as asthma candidate gene

BMC Medical Genetics

Table 5 Genotyping results for rs2941504.

	Genetic Model	Genotype/Allele^d	Affected^e	Unaffected^f	P value^g	OR	95% CI^h
	General	GG/AG/AA	93/449/467	170/432/410	1.48 × 10^-6	0.526 0.480	(0.396-0.700) (0.361-0.639)
	Multiplicative	G/A	635/1383	772/1252	9.56 × 10^-6	0.745	(0.654-0.848)
1011 vs	Additive	G/A	635/1383	772/1252	1.25 × 10^-5	0.745	(0.654-0.848)
1014 ^a	Dominant	GG+AG/AA	542/467	602/410	9.25 × 10^-3	0.790	(0.663-0.943)
	Recessive	GG/AG+AA	93/916	170/842	4.34 × 10^-7	0.503	(0.384-0.658)
1011 vs	General	GG/AG/AA	93/449/467	163/644/570	2.25 × 10^-2	0.818 0.696	(0.617-1.085) (0.525-0.924)
1445 ^b	Multiplicative	G/A	635/1383	970/1784	6.97 × 10^-3	0.845	(0.747-0.954)
1445 vs	General	GG/AG/AA	163/644/570	170/432/410	1.96 × 10^-3	0.643 0.690	(0.502-0.823) (0.537-0.885)
1014 ^c	Multiplicative	G/A	970/1784	772/1252	3.87 × 10^-2	0.882	(0.783-0.993)

a) Genotyping results for 1011 case versus 1014 control samples comparison; b) Genotyping results for 1011 case versus 1445 atopic samples comparison; c) Genotyping results for 1445 atopic versus 1014 control samples comparison; d) Order of genotype and/or allele counts listed in columns e) and f); g) P values from a Fisher's test using a 3 × 2 table for General genetic model, a 2 × 2 table for Multiplicative, Dominant or Recessive models, and P value from a Cochran Armitage Trend test for Additive model; h) Odds ratio and 95% confidence interval calculated for the AG and AA genotypes respectively using GG as the reference under the General model, for the A allele using G as the reference under the Multiplicative and Additive models, for the AA genotype using GG and AG as the reference under the Dominant model, and for the AG and AA genotypes using GG as the reference under the Recessive model.

ISSN: 1471-2350