Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer

BMC Medical Genetics201011:95

DOI: 10.1186/1471-2350-11-95

Received: 21 April 2010

Accepted: 14 June 2010

Published: 14 June 2010

Correction

The authors would like to apologize for failing to attribute text in their manuscript [1]. The following sentences were not referenced correctly as a direct quotation:

"Ras protein is activated transiently as a response to extracellular signals, such as growth factors, cytokines, and hormones that stimulate cell surface receptors. It can switch between an inactive state, in which the proteins are bound to guanosine-diphosphates, and an active state, in which conversion to guanosine- triphosphate (GTP) occurs. Mutant activated forms of Ras proteins have an impaired intrinsic GTPase activity, which renders the protein resistant to inactivation by regulatory GTPase-activating proteins" [2].

In addition, the following errors were made in the Abstract, paragraph 2 of the Results and Table two of the original publication [1]:
  1. 1.

    The methods described in the Abstract as "polymerase chain reaction-single strand conformational polymorphism" should be "polymerase chain reaction and Sanger sequencing".

     
  2. 2.

    The sentence in the Results (paragraph 2) "leading to substitution of a glutamine by leucine acid (Gln849Leu)" should be replaced by "leading to substitution of a Lysine by Arginine (Lys728Arg)." The sentence "leading to transitions of Lys728Arg and Ala871Thr." should be "leading to transitions of Gln849Leu and Ala871Thr."

     
  3. 3.

    In the EGFR column of Table two of the original publication, Gln849Leu in the first row should be replaced by Lys728Arg. In the second row of the same column, Lys728Arg should be replaced by Gln849Leu. The corrections are shown in Table 1.

     
Table 1

Corrections to Table two "Epidermal growth factor receptor and K-ras mutations"

 

Site

Wild type

Type of point mutation

Number of mutations (%)

Amino acid

Heterozygous/homozygous

EGFRa

Exon 18

AAG

2183A>G

1 (33.3)

Lys728Arg

Heterozygous

 

Exon 21

CAG

2546A>T

1 (33.3)

Gln849Leu

Heterozygous

 

Exon 21

GCA

2611G>A

1 (33.3)

Ala871Thr

Heterozygous

K-ras

Codon 12

GGT

35G>A

16 (47.1)

Gly12Asp

Heterozygous

 

Codon 12

GGT

34G>T

6 (17.6)

Gly12Cys

Heterozygous

 

Codon 12

GGT

34G>A

3 (8.8)

Gly12Ser

Heterozygous

 

Codon 12

GGT

34G>A

1 (2.9)

Gly12Ser

Homozygous

 

Codon 12

GGT

34G>T

1 (2.9)

Gly12Cys

Homozygous

 

Codon 12

GGT

35G>C

1 (2.9)

Gly12Ala

Heterozygous

 

Codon 12

GGT

35G>A

1 (2.9)

Gly12Asp

Homozygous

 

Codon 12

GGT

35G>T

1 (2.9)

Gly12Val

Heterozygous

 

Codon 13

GGC

38G>A

1 (2.9)

Gly13Asp

Heterozygous

 

Codon 45

GTA

133G>A

1 (2.9)

Val45Ile

Homozygous

 

Codon 69

GAC

205G>A

1 (2.9)

Asp69Asn

Homozygous

 

Codon 80

TGT

239G>A

1 (2.9)

Cys80Tyr

Heterozygous

Corrections to Table 2 "Epidermal growth factor receptor and K-ras mutations" in the original publication [1] are shown in Table 1 of this Correction as follows: In the EGFR column of Table 2, Gln849Leu in the first row should be replaced by Lys728Arg. In the second row of the EGFR column, Lys728Arg should be replaced by Gln849Leu, as shown in Table 1 of this Correction.

Authors’ Affiliations

(1)
Department of Medical Oncology, Fudan University Cancer Hospital, Shanghai Medical School
(2)
Innovation Center China, AstraZeneca Global R&D

References

  1. Zuo Y, Cao J, Zhu G, Lu Y, Zhou X, Li J: Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer. BMC Medical Genetics 2010, 11: 34.
  2. Brink M, de Goeij AF, Weijenberg MP, Roemen GM, Lentjes MH, Pachen MM, Smits KM, de Bruïne AP, Goldbohm RA, van den Brandt PA: K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis 2003, 24: 703–710.View ArticlePubMed
  3. Pre-publication history

    1. The pre-publication history for this paper can be accessed here:http://​www.​biomedcentral.​com/​1471-2350/​11/​95/​prepub

Copyright

© Yunxia et al. 2010

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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