From: Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion
SNP | rs6235 (encoding S690T) | |||||
---|---|---|---|---|---|---|
Genotype | GG | GC | CC | βadj ± SEM | pdom | padd |
N (f/m) | 817(537/280) | 560(377/183) | 108(72/36) | - | - | - |
Age (years) | 39 ± 1 | 40 ± 1 | 38 ± 1 | - | - | - |
BMI (kg/m2) | 28.2 ± 0.3 | 28.7 ± 0.3 | 29.3 ± 0.8 | 0.016 ± 0.010 | 0.2 | 0.3 |
Waist circumference (cm) | 92.9 ± 0.6 | 93.9 ± 0.7 | 94.9 ± 2.0 | 0.009 ± 0.007 | 0.2 | 0.9 |
Total body fat (%) | 30.7 ± 0.4 | 31.0 ± 0.5 | 31.7 ± 1.0 | 0.014 ± 0.014 | 0.7 | 0.5 |
Fasting glucose (mmol/l) | 5.1 ± 0.1 | 5.1 ± 0.1 | 5.1 ± 0.1 | -0.004 ± 0.004 | 0.2 | 0.3 |
Glucose120-min (mmol/l) | 6.2 ± 0.1 | 6.3 ± 0.1 | 6.3 ± 0.2 | 0.005 ± 0.011 | 0.7 | 0.8 |
Fasting insulin (pmol/l) | 61 ± 2 | 64 ± 2 | 63 ± 5 | 0.021 ± 0.027 | 0.8 | 0.6 |
Insulin sensitivity, OGTT (AU) | 16.8 ± 0.4 | 16.4 ± 0.5 | 16.0 ± 0.9 | -0.018 ± 0.029 | 0.7 | 0.7 |
Insulin sensitivity, clamp-derived (AU) (N = 512) | 0.088 ± 0.003 (N = 286) | 0.080 ± 0.004 (N = 191) | 0.091 ± 0.009 (N = 35) | -0.023 ± 0.021 | 0.3 | 0.4 |
HOMAIR (mU × mmol × l-2) | 2.4 ± 0.1 | 2.5 ± 0.1 | 2.5 ± 0.2 | 0.017 ± 0.029 | 0.9 | 0.6 |
AUCIns30/AUCGlc30 (×10-9) | 40.4 ± 1.0 | 40.2 ± 1.3 | 46.0 ± 3.7 | 0.022 ± 0.026 | 0.9 | 0.6 |
First-phase insulin (pmol/l) | 1247 ± 29 | 1251 ± 35 | 1383 ± 97 | 0.014 ± 0.024 | 1.0 | 1.0 |
AUCC-Pep/AUCGlc (×10-9) | 318 ± 3.6 | 316 ± 4.4 | 343 ± 13 | 0.017 ± 0.014 | 1.0 | 0.2 |
Proinsulin0-min (pmol/l) | 5.6 ± 0.2 | 5.9 ± 0.3 | 7.0 ± 0.9 | 0.081 ± 0.041 | 0.1 | 0.1 |
Proinsulin30-min (pmol/l) | 11.2 ± 0.3 | 12.2 ± 0.7 | 16.5 ± 2.6 | 0.117 ± 0.038 | 0.0286 | 0.0059 |
AUCProins (pmol/l) | 34.2 ± 1.0 | 37.0 ± 1.5 | 49.1 ± 6.7 | 0.105 ± 0.034 | 0.0404 | 0.0018 |
Fasting proinsulin/fasting insulin | 0.126 ± 0.004 | 0.129 ± 0.003 | 0.147 ± 0.014 | 0.062 ± 0.044 | 0.2 | 0.1 |
Proinsulin30-min/insulin30-min | 0.036 ± 0.005 | 0.035 ± 0.002 | 0.047 ± 0.011 | 0.105 ± 0.041 | 0.0208 | 0.0123 |
AUCProins/AUCIns | 0.048 ± 0.001 | 0.053 ± 0.003 | 0.068 ± 0.011 | 0.085 ± 0.035 | 0.0324 | 0.0090 |