SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in african-americans of the GENOA study

Table 5 Positional and functional details of SNPs included in the final multivariable model.

SNP	Gene	Chromo-some	Position	Minor Allele	Minor Allele Freq.	Type	Biological Processes*	HWE p-value	P-value for Main Effect of SNP
rs35314437	MPO	17q	53704206	G	0.015	Synonymous	Response to oxidative stress, anti-apoptosis	1	0.044
rs7552841	PCSK9	1p	55291340	A	0.237	Intron	Cholesterol homeostasis & metabolic processes	0.6532	0.0215
rs257376	PRKAR2B	7q	106393948	A	0.486	Synonymous	Intra-cellular signaling cascade	0.5951	0.0512
rs5267	NPPC	2q	232615776	T	0.196	Non-synonymous	Regulation of BP & vasoconstriction	0.7323	0.0067
rs17876148	PON2	7q	94877484	A	0.093	Intron	None reported	0.0017	0.1564
rs12971616	CARM1	19p	10875937	A	0.13	Intron	Transcription regulation, histone methylation	0.1464	0.4149
rs6745660	HSPD1	2q	198057781	G	0.351	3' near gene	Protein folding, response to stress	0.0625	0.0188
rs12460421	CARM1	19p	10842352	G	0.438	5' near gene	Transcription regulation, histone methylation	0.6796	9.24 × 10^-4

* Biological process of the gene are a subset of those reported in the Michigan Molecular Interactions website: http://mimi.ncibi.org/MimiWeb/main-page.jsp

ISSN: 1471-2350