SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in african-americans of the GENOA study

Table 2 Summary of the number of associations passing each of the three multiple testing criteria.

This table outlines the number of associations (single SNP, SNP-covariate interactions, and SNP-SNP interactions) passing each level of multiple testing criteria (False Discovery Rate (FDR), 4-fold cross validation (CV) repeated and averaged 10 times, and internal replication in two subsets of the full dataset). The intersection of associations passing all three criteria reveals little overlap.
*P-values for SNP main effects are from a 2 degree of freedom likelihood ratio test statistic. The SNP-covariate and SNP-SNP interactions p-values were determined from a likelihood ratio test comparing a full model (including all interactions and main effects) to a reduced model only containing main effects of covariates and/or SNPs.

ISSN: 1471-2350