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Table 3 Significant associations of candidate gene polymorphisms and albumin-to-creatinine ratioa, additive genetic model

From: Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

 

Crude Model

Fully AdjustedbModel

Variant

β coefficient (95% CI)

P-value

FDR-adjusted P-value

β coefficient (95% CI)

P-value

FDR-adjusted P-value

Non-Hispanic whites

      

rs1801274 (FCGR2A)

0.07 (-0.01-0.14)

0.0884

0.7950

0.09 (0.01-0.17)

0.0308

0.5610

rs1800790 (FGB)

-0.07 (-0.15-0.01)

0.0854

0.7950

-0.08 (-0.17--0.00)

0.0417

0.5610

rs11003125 (MBL2)

0.10 (0.03-0.17)

0.0058

0.1300

0.09 (0.02-0.15)

0.0131

0.3930

rs9282799 (NOS2A)

1.31 (0.58-2.04)

0.0011

0.0660

0.81 (0.00-1.62)

0.0490

0.5610

rs1800750 (TNF)

0.41 (0.13-0.70)

0.0065

0.1300

0.35 (0.09-0.60)

0.0092

0.3930

Non-Hispanic blacks

      

rs1205 (CRP)

-0.11 (-0.25-0.04)

0.1441

0.7663

-0.15 (-0.29--0.00)

0.0441

0.5471

rs1799963 (F2)

-0.88 (-2.20-0.44)

0.1810

0.7663

-0.96 (-1.88--0.04)

0.0411

0.5471

rs1800468 (TGFB1/B9D2)

-0.34 (-0.65--0.03)

0.0328

0.7663

-0.33 (-0.70-0.04)

0.0750

0.5471

Mexican Americans

      

rs1800482 (NOS2A)

-0.06 (-0.69-0.57)

0.8458

0.9877

-0.32 (-0.58--0.06)

0.0176

0.3520

rs9282799 (NOS2A)

0.67 (0.29-1.05)

0.0014

0.0840

0.58 (-0.44-1.59)

0.2513

0.9466

rs1799983 (NOS3)

-0.12 (-0.30-0.06)

0.1699

0.8693

-0.18 (-0.32--0.04)

0.0145

0.3520

rs1799762 (SERPINE1)

0.10 (0.01-0.19)

0.0295

0.5900

0.03 (-0.07-0.12)

0.5637

0.9466

  1. CI, confidence interval; FDR, false-discovery rate.
  2. a) Defined as log-transformed albumin-to-creatinine ratio (ACR) and analyzed as a continuous variable. b) Analyses adjusted for age, sex, alcohol consumption, educational attainment, and waist:hip ratio.
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BMC Medical Genetics

ISSN: 1471-2350

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