Table 2 SLC2A10 sequence variants and association with PAD in type 2 diabetic patients at baseline.
# | ID | Position (kb) | Function | Major/ minor allele | Minor allele frequency PAD(-) PAD(+) | Allelic p-value (adjusted*) | Allele OR* (95% CI) | Genotype distribution** PAD (-) PAD (+) | Genotypic p-value (adjusted*) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | rs2425895 | -1.789 | 5' upstream | G/A | 0.067 | 0.056 | 0.75 (0.83) | 0.87 (0.24-3.13) | 301:42:2 | 24:3:0 | 1.00 (0.82) |
2 | (TGTGTGTGT)n | -0.208 | 5' upstream | 3/2 | 0.24 | 0.28 | 0.54 (0.38) | 1.37 (0.68-2.80) | 198:128:18 | 14:11:2 | 0.72 (0.39) |
3 | rs2143044 | 10.341 | Intron 1 | C/T | 0.31 | 0.44 | 0.03 (0.03) | 2.00 (1.04-3.85) | 167:141:35 | 7:16:4 | 0.05 (0.04) |
4 | rs3092412 | 11.720 | Intron 1 | A/T | 0.39 | 0.56 | 0.01 (0.005) | 2.51 (1.31-4.81) | 130:164:51 | 4:16:7 | 0.03 (0.006) |
5 | rs2235491 | 15.915 | Exon 2 Ala206Thr | G/A | 0.074 | 0.13 | 0.14 (0.036) | 3.03 (1.08-8.55) | 296:47:2 | 21:5:1 | 0.11 (0.05) |
6 | rs2425904 | 18.500 | Intron 3 | T/C | 0.37 | 0.56 | 0.007 (0.004) | 2.58 (1.34-4.98) | 133:167:45 | 3:18:6 | 0.006 (0.004) |
7 | rs2425911 | 21.843 | Intron 4 | G/C | 0.38 | 0.56 | 0.01 (0.005) | 2.54 (1.32-4.87) | 132:164:49 | 3:8:6 | 0.009 (0.005) |
8 | rs3091904 | 23.079 | Intron 4 | C/T | 0.38 | 0.57 | 0.004 (0.002) | 2.83 (1.46-5.46) | 136:158:51 | 3:17:7 | 0.005 (0.002) |
9 | rs1059217 | 26.273 | 3' UTR | C/T | 0.37 | 0.56 | 0.007 (0.004) | 2.58 (1.35-4.95) | 185:160:0 | 9:18:0 | 0.005 (0.004) |
10 | rs6066059 | 29.778 | 3' downstream | C/T | 0.37 | 0.56 | 0.005 (0.004) | 2.61 (1.36-5.00) | 138:161:46 | 3:18:6 | 0.004 (0.004) |
11 | rs2179357 | 32.708 | 3' downstream | C/T | 0.33 | 0.57 | 2.6 × 10 -4 (< 0.0001) | 3.87 (1.97-7.58) | 160:143:42 | 4:15:8 | 0.001 (< 0.0001) |