Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals

Table 4 Statistical Analysis of ApoB, LPL and Leptin loci in normotensive, obese and hypertensive individuals.

	No. of alleles observed	Predominant Allele (repeat/bp)	No. of genotypes observed	Predominant genotype (repeat/bp)	Observed Heterozygosity	Expected Heterozygosity	PIC	PD	H-W equilibrium (P value)
ApoB locus
Normal (N = 33)	11	37	18	37-37	0.61	0.83	0.80	0.93	P = 0.623
Obese (N = 34)	8	37	15	37-37, 37-39, 39-39	0.62	0.78	0.74	0.91	P = 0.358
Hypertensive (N = 46)	13	39	24	37-37	0.63	0.83	0.78	0.92	P = 0.877
LPL locus
Normal (N = 29)	5	9	9	9-9	0.83	0.74	0.68	0.84	P = 0.156
Obese (N = 33)	4	9	7	9-9	0.70	0.67	0.61	0.81	P = 0.094
Hypertensive (N = 44)	6	9	10	9-10, 9-11	0.62	0.64	0.58	0.81	P = 0.939
Leptin locus
Normal (N = 29)	13	152, 156	23	152-156	0.76	0.85	0.82	0.94	P = 0.977
Obese (N = 33)	14	152	23	152-152	0.83	0.86	0.83	0.94	P = 0.999
Hypertensive (N = 44)	13	152	27	152-152, 224-228	0.77	0.88	0.87	0.94	P = 0.162

N = Number of samples, PIC = Polymorphic Information Content, PD = Power of Discrimination,
H-W:Hardy Weinberg

ISSN: 1471-2350